Welcome to the Helleday Laboratory
Our aim to improve science, health and society!
Our commitment doesn’t stop with with science at the basics; we bring our results all the way to the patients.
The Helleday Laboratory consists of a large team of mixed professions; basic molecular biologists, medicinal chemists from industry and academia, pharmacologists, biochemists and practicing clinicians, amongst others.
What brings us together is our dedication to make our basic science discoveries reach all the way to helping patients stay healthy and with their loved ones!
The Helleday Laboratory mostly focuses on metabolism and DNA repair.
The Nobel Prize laureate Otto Warburg pioneered cancer metabolism research and coined that “The cure of human cancer will be the resultant of biochemistry of cancer and of biochemistry of man“. We think he was right, and with the molecular knowledge of altered metabolic pathways in cancer of today we can make real advances in progressing treatments. Read about how we target glucose metabolism and nucleotide metabolism.
Chemo- and radiotherapy is still the backbone of cancer treatments, and they work by causing damage to the cancer cells DNA. We know today that cancer cells have a high load of DNA damage as compared to normal cells. Read about DNA damage and repair in cancer. Previously, the Helleday lab has exploited this and shown that PARP inhibitors selectively kill recombination defective cancers, such as inherited breast- and ovarian cancer. This is now an approved treatment and help patients across the world.
“I am happy and impressed by your work. Words can not describe how grateful I am; not only for my sake but for my children and family as well. It gives me hope to break the chain of cancer in the family. I hope for the drug to reach the market soon so more can be treated.” Translated from SwedishMarie
Many diseases have alterations in metabolic pathways often leading to DNA damage that manifest or define the disease. Our strategy is to identify basic mechanisms of proteins involved in metabolism and DNA repair to gain better understanding in disease and also develop small molecule inhibitors to selectively targeting these proteins as potential therapeutics. We reach our goal through open innovation and through a foundation, securing the future for our science and ensuring long term benefit to mankind.