Ann-Sofie Jemth


Published at Helleday Laboratory

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Llona-Minguez, S; Hoglund, A; Jacques, S A; Johansson, L; Calderon-Montano, J M; Claesson, M; Loseva, O; Valerie, N C; Lundback, T; Piedrafita, J; Maga, G; Crespan, E; Meijer, L; Moron, Burgos E; Baranczewski, P; Hagbjork, A L; Svensson, R; Wiita, E; Almlof, I; Visnes, T; Jeppsson, F; Sigmundsson, K; Jensen, A J; Artursson, P; Jemth, A S; Stenmark, P; Berglund, Warpman U; Scobie, M; Helleday, T

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 Journal Article

J. Med. Chem., 59 (3), pp. 1140–1148, 2016, ([PubMed Central:href] [DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:

Brautigam, L; Pudelko, L; Jemth, A S; Gad, H; Narwal, M; Gustafsson, R; Karsten, S; Carreras-Puigvert, J; Homan, E; Berndt, C; Berglund, Warpman U; Stenmark, P; Helleday, T

Hypoxic signaling and the cellular redox tumor environment determine sensitivity to MTH1 inhibition Journal Article

Cancer Res., 2016, ([DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:

Reddy, P T; Jaruga, P; Nelson, B C; Lowenthal, M S; Jemth, A S; Loseva, O; Coskun, E; Helleday, T; Dizdaroglu, M

Production, Purification, and Characterization of (15)N-Labeled ĐNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements Journal Article

Meth. Enzymol., 566 , pp. 305–332, 2016, ([DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:


Coskun, E; Jaruga, P; Jemth, A S; Loseva, O; Scanlan, L D; Tona, A; Lowenthal, M S; Helleday, T; Dizdaroglu, M

Addiction to MŦĦ1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry Journal Article

DNA Repair (Amst.), 33 , pp. 101–110, 2015, ([DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:

Palazzo, L; Thomas, B; Jemth, A S; Colby, T; Leidecker, O; Feijs, K L; Zaja, R; Loseva, O; Puigvert, J C; Matic, I; Helleday, T; Ahel, I

Processing of protein AĐP-ribosylation by Nudix hydrolases Journal Article

Biochem. J., 468 (2), pp. 293–301, 2015, ([DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:

Carter, M; Jemth, A S; Hagenkort, A; Page, B D; Gustafsson, R; Griese, J J; Gad, H; Valerie, N C; Desroses, M; Bostrom, J; Berglund, Warpman U; Helleday, T; Stenmark, P

Crystal structure, biochemical and cellular activities demonstrate separate functions of MŦĦ1 and MŦĦ2 Journal Article

Nat Commun, 6 , pp. 7871, 2015, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Huber, K V; Salah, E; Radic, B; Gridling, M; Elkins, J M; Stukalov, A; Jemth, A S; Gokturk, C; Sanjiv, K; Stromberg, K; Pham, T; Berglund, U W; Colinge, J; Bennett, K L; Loizou, J I; Helleday, T; Knapp, S; Superti-Furga, G

Stereospecific targeting of MŦĦ1 by (S)-crizotinib as an anticancer strategy Journal Article

Nature, 508 (7495), pp. 222–227, 2014, ([PubMed Central:href] [DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:

Gad, H; Koolmeister, T; Jemth, A S; Eshtad, S; Jacques, S A; Strom, C E; Svensson, L M; Schultz, N; Lundback, T; Einarsdottir, B O; Saleh, A; Gokturk, C; Baranczewski, P; Svensson, R; Berntsson, R P; Gustafsson, R; Stromberg, K; Sanjiv, K; Jacques-Cordonnier, M C; Desroses, M; Gustavsson, A L; Olofsson, R; Johansson, F; Homan, E J; Loseva, O; Brautigam, L; Johansson, L; Hoglund, A; Hagenkort, A; Pham, T; Altun, M; Gaugaz, F Z; Vikingsson, S; Evers, B; Henriksson, M; Vallin, K S; Wallner, O A; Hammarstrom, L G; Wiita, E; Almlof, I; Kalderen, C; Axelsson, H; Djureinovic, T; Puigvert, J C; Haggblad, M; Jeppsson, F; Martens, U; Lundin, C; Lundgren, B; Granelli, I; Jensen, A J; Artursson, P; Nilsson, J A; Stenmark, P; Scobie, M; Berglund, U W; Helleday, T

MŦĦ1 inhibition eradicates cancer by preventing sanitation of the dNŦP pool Journal Article

Nature, 508 (7495), pp. 215–221, 2014, ([DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:


Svensson, L M; Jemth, A S; Desroses, M; Loseva, O; Helleday, T; Hogbom, M; Stenmark, P

Crystal structure of human MŦĦ1 and the 8-oxo-dGMP product complex Journal Article

FEBS Lett., 585 (16), pp. 2617–2621, 2011, ([DOI:href] [PubMed:href]).

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Loseva, O; Jemth, A S; Bryant, H E; Schuler, H; Lehtio, L; Karlberg, T; Helleday, T

PARP-3 is a mono-AĐP-ribosylase that activates PARP-1 in the absence of ĐNA Journal Article

J. Biol. Chem., 285 (11), pp. 8054–8060, 2010, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Bryant, H E; Petermann, E; Schultz, N; Jemth, A S; Loseva, O; Issaeva, N; Johansson, F; Fernandez, S; McGlynn, P; Helleday, T

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination Journal Article

EMBO J., 28 (17), pp. 2601–2615, 2009, ([PubMed Central:href] [DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:

Lehtio, L; Jemth, A S; Collins, R; Loseva, O; Johansson, A; Markova, N; Hammarstrom, M; Flores, A; Holmberg-Schiavone, L; Weigelt, J; Helleday, T; Schuler, H; Karlberg, T

Structural basis for inhibitor specificity in human poly(AĐP-ribose) polymerase-3 Journal Article

J. Med. Chem., 52 (9), pp. 3108–3111, 2009, ([DOI:href] [PubMed:href]).

Abstract | BibTeX | Tags:

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