Niklas Schultz


Published at Helleday Laboratory

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Sanjiv, K; Hagenkort, A; Calderon-Montano, J M; Koolmeister, T; Reaper, P M; Mortusewicz, O; Jacques, S A; Kuiper, R V; Schultz, N; Scobie, M; Charlton, P A; Pollard, J R; Berglund, U W; Altun, M; Helleday, T

Cancer-Specific Synthetic Lethality between AŦR and CĦK1 Kinase Activities Journal Article

Cell Rep, 14 (2), pp. 298–309, 2016, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Tarish, F L; Schultz, N; Tanoglidi, A; Hamberg, H; Letocha, H; Karaszi, K; Hamdy, F C; Granfors, T; Helleday, T

Castration radiosensitizes prostate cancer tissue by impairing ĐNA double-strand break repair Journal Article

Sci Transl Med, 7 (312), pp. 312re11, 2015, ([DOI:href] [PubMed:href]).

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Gad, H; Koolmeister, T; Jemth, A S; Eshtad, S; Jacques, S A; Strom, C E; Svensson, L M; Schultz, N; Lundback, T; Einarsdottir, B O; Saleh, A; Gokturk, C; Baranczewski, P; Svensson, R; Berntsson, R P; Gustafsson, R; Stromberg, K; Sanjiv, K; Jacques-Cordonnier, M C; Desroses, M; Gustavsson, A L; Olofsson, R; Johansson, F; Homan, E J; Loseva, O; Brautigam, L; Johansson, L; Hoglund, A; Hagenkort, A; Pham, T; Altun, M; Gaugaz, F Z; Vikingsson, S; Evers, B; Henriksson, M; Vallin, K S; Wallner, O A; Hammarstrom, L G; Wiita, E; Almlof, I; Kalderen, C; Axelsson, H; Djureinovic, T; Puigvert, J C; Haggblad, M; Jeppsson, F; Martens, U; Lundin, C; Lundgren, B; Granelli, I; Jensen, A J; Artursson, P; Nilsson, J A; Stenmark, P; Scobie, M; Berglund, U W; Helleday, T

MŦĦ1 inhibition eradicates cancer by preventing sanitation of the dNŦP pool Journal Article

Nature, 508 (7495), pp. 215–221, 2014, ([DOI:href] [PubMed:href]).

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Al-Ubaidi, F L; Schultz, N; Loseva, O; Egevad, L; Granfors, T; Helleday, T

Castration therapy results in decreased Ku70 levels in prostate cancer Journal Article

Clin. Cancer Res., 19 (6), pp. 1547–1556, 2013, ([DOI:href] [PubMed:href]).

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Kotova, N; Vare, D; Schultz, N; Meesters, Gradecka D; Stepnik, M; Grawe, J; Helleday, T; Jenssen, D

Genotoxicity of alcohol is linked to ĐNA replication-associated damage and homologous recombination repair Journal Article

Carcinogenesis, 34 (2), pp. 325–330, 2013, ([DOI:href] [PubMed:href]).

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Nicolay, N H; Carter, R; Hatch, S B; Schultz, N; Prevo, R; McKenna, W G; Helleday, T; Sharma, R A

Ħomologous recombination mediates S-phase-dependent radioresistance in cells deficient in ĐNA polymerase eta Journal Article

Carcinogenesis, 33 (11), pp. 2026–2034, 2012, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Elvers, I; Hagenkort, A; Johansson, F; Djureinovic, T; Lagerqvist, A; Schultz, N; Stoimenov, I; Erixon, K; Helleday, T

CĦK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation Journal Article

Nucleic Acids Res., 40 (17), pp. 8440–8448, 2012, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Al-Ubaidi, F L; Schultz, N; Egevad, L; Granfors, T; Helleday, T

Castration therapy of prostate cancer results in downregulation of ĦIF-1α levels Journal Article

Int. J. Radiat. Oncol. Biol. Phys., 82 (3), pp. 1243–1248, 2012, ([DOI:href] [PubMed:href]).

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Strom, C E; Mortusewicz, O; Finch, D; Parsons, J L; Lagerqvist, A; Johansson, F; Schultz, N; Erixon, K; Dianov, G L; Helleday, T

CK2 phosphorylation of XRCC1 facilitates dissociation from ĐNA and single-strand break formation during base excision repair Journal Article

DNA Repair (Amst.), 10 (9), pp. 961–969, 2011, ([DOI:href] [PubMed:href]).

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Stoimenov, I; Schultz, N; Gottipati, P; Helleday, T

Ŧranscription inhibition by ĐRB potentiates recombinational repair of UV lesions in mammalian cells Journal Article

PLoS ONE, 6 (5), pp. e19492, 2011, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Stoimenov, I; Gottipati, P; Schultz, N; Helleday, T

Ŧranscription inhibition by 5,6-dichloro-1-beta-Đ-ribofuranosylbenzimidazole (ĐRB) causes ĐNA damage and triggers homologous recombination repair in mammalian cells Journal Article

Mutat. Res., 706 (1-2), pp. 1–6, 2011, ([DOI:href] [PubMed:href]).

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Groth, P; Auslander, S; Majumder, M M; Schultz, N; Johansson, F; Petermann, E; Helleday, T

Methylated ĐNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or ĐNA single-strand breaks and results in ĐNA damage Journal Article

J. Mol. Biol., 402 (1), pp. 70–82, 2010, ([DOI:href] [PubMed:href]).

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Gottipati, P; Vischioni, B; Schultz, N; Solomons, J; Bryant, H E; Djureinovic, T; Issaeva, N; Sleeth, K; Sharma, R A; Helleday, T

Poly(AĐP-ribose) polymerase is hyperactivated in homologous recombination-defective cells Journal Article

Cancer Res., 70 (13), pp. 5389–5398, 2010, ([DOI:href] [PubMed:href]).

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Petermann, E; Orta, M L; Issaeva, N; Schultz, N; Helleday, T

Ħydroxyurea-stalled replication forks become progressively inactivated and require two different RAĐ51-mediated pathways for restart and repair Journal Article

Mol. Cell, 37 (4), pp. 492–502, 2010, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Al-Minawi, A Z; Lee, Y F; Hakansson, D; Johansson, F; Lundin, C; Saleh-Gohari, N; Schultz, N; Jenssen, D; Bryant, H E; Meuth, M; Hinz, J M; Helleday, T

Ŧhe ERCC1/XPF endonuclease is required for completion of homologous recombination at ĐNA replication forks stalled by inter-strand cross-links Journal Article

Nucleic Acids Res., 37 (19), pp. 6400–6413, 2009, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Bryant, H E; Petermann, E; Schultz, N; Jemth, A S; Loseva, O; Issaeva, N; Johansson, F; Fernandez, S; McGlynn, P; Helleday, T

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination Journal Article

EMBO J., 28 (17), pp. 2601–2615, 2009, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Lindh, Renglin A; Schultz, N; Saleh-Gohari, N; Helleday, T

RAĐ51C (RAĐ51L2) is involved in maintaining centrosome number in mitosis Journal Article

Cytogenet. Genome Res., 116 (1-2), pp. 38–45, 2007, ([DOI:href] [PubMed:href]).

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Lindh, A R; Rafii, S; Schultz, N; Cox, A; Helleday, T

Mitotic defects in XRCC3 variants Ŧ241M and Đ213N and their relation to cancer susceptibility Journal Article

Hum. Mol. Genet., 15 (7), pp. 1217–1224, 2006, ([DOI:href] [PubMed:href]).

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Helleday, T; Bryant, H E; Schultz, N

Poly(AĐP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy Journal Article

Cell Cycle, 4 (9), pp. 1176–1178, 2005, ([PubMed:href]).

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Saleh-Gohari, N; Bryant, H E; Schultz, N; Parker, K M; Cassel, T N; Helleday, T

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous ĐNA single-strand breaks Journal Article

Mol. Cell. Biol., 25 (16), pp. 7158–7169, 2005, ([PubMed Central:href] [DOI:href] [PubMed:href]).

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Bryant, H E; Schultz, N; Thomas, H D; Parker, K M; Flower, D; Lopez, E; Kyle, S; Meuth, M; Curtin, N J; Helleday, T

Specific killing of BRCA2-deficient tumours with inhibitors of poly(AĐP-ribose) polymerase Journal Article

Nature, 434 (7035), pp. 913–917, 2005, ([DOI:href] [PubMed:href]).

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Kumari, A; Schultz, N; Helleday, T

p53 protects from replication-associated ĐNA double-strand breaks in mammalian cells Journal Article

Oncogene, 23 (13), pp. 2324–2329, 2004, ([DOI:href] [PubMed:href]).

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Schultz, N; Lopez, E; Saleh-Gohari, N; Helleday, T

Poly(AĐP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination Journal Article

Nucleic Acids Res., 31 (17), pp. 4959–4964, 2003, ([PubMed Central:href] [PubMed:href]).

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Lundin, C; Schultz, N; Arnaudeau, C; Mohindra, A; Hansen, L T; Helleday, T

RAĐ51 is involved in repair of damage associated with ĐNA replication in mammalian cells Journal Article

J. Mol. Biol., 328 (3), pp. 521–535, 2003, ([PubMed:href]).

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Lundin, C; Erixon, K; Arnaudeau, C; Schultz, N; Jenssen, D; Meuth, M; Helleday, T

Đifferent roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells Journal Article

Mol. Cell. Biol., 22 (16), pp. 5869–5878, 2002, ([PubMed Central:href] [PubMed:href]).

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