Niklas Schultz

Biologist

Published at Helleday Laboratory

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2016

Sanjiv, K; Hagenkort, A; Calderon-Montano, J M; Koolmeister, T; Reaper, P M; Mortusewicz, O; Jacques, S A; Kuiper, R V; Schultz, N; Scobie, M; Charlton, P A; Pollard, J R; Berglund, U W; Altun, M; Helleday, T

Cancer-Specific Synthetic Lethality between AŦR and CĦK1 Kinase Activities Journal Article

Cell Rep, 14 (2), pp. 298–309, 2016, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713868PMC4713868] [DOI:hrefhttp://dx.doi.org/10.1016/j.celrep.2015.12.03210.1016/j.celrep.2015.12.032] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2674870926748709]).

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2015

Tarish, F L; Schultz, N; Tanoglidi, A; Hamberg, H; Letocha, H; Karaszi, K; Hamdy, F C; Granfors, T; Helleday, T

Castration radiosensitizes prostate cancer tissue by impairing ĐNA double-strand break repair Journal Article

Sci Transl Med, 7 (312), pp. 312re11, 2015, ([DOI:hrefhttp://dx.doi.org/10.1126/scitranslmed.aac567110.1126/scitranslmed.aac5671] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2653725926537259]).

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2014

Gad, H; Koolmeister, T; Jemth, A S; Eshtad, S; Jacques, S A; Strom, C E; Svensson, L M; Schultz, N; Lundback, T; Einarsdottir, B O; Saleh, A; Gokturk, C; Baranczewski, P; Svensson, R; Berntsson, R P; Gustafsson, R; Stromberg, K; Sanjiv, K; Jacques-Cordonnier, M C; Desroses, M; Gustavsson, A L; Olofsson, R; Johansson, F; Homan, E J; Loseva, O; Brautigam, L; Johansson, L; Hoglund, A; Hagenkort, A; Pham, T; Altun, M; Gaugaz, F Z; Vikingsson, S; Evers, B; Henriksson, M; Vallin, K S; Wallner, O A; Hammarstrom, L G; Wiita, E; Almlof, I; Kalderen, C; Axelsson, H; Djureinovic, T; Puigvert, J C; Haggblad, M; Jeppsson, F; Martens, U; Lundin, C; Lundgren, B; Granelli, I; Jensen, A J; Artursson, P; Nilsson, J A; Stenmark, P; Scobie, M; Berglund, U W; Helleday, T

MŦĦ1 inhibition eradicates cancer by preventing sanitation of the dNŦP pool Journal Article

Nature, 508 (7495), pp. 215–221, 2014, ([DOI:hrefhttp://dx.doi.org/10.1038/nature1318110.1038/nature13181] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2469522424695224]).

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2013

Al-Ubaidi, F L; Schultz, N; Loseva, O; Egevad, L; Granfors, T; Helleday, T

Castration therapy results in decreased Ku70 levels in prostate cancer Journal Article

Clin. Cancer Res., 19 (6), pp. 1547–1556, 2013, ([DOI:hrefhttp://dx.doi.org/10.1158/1078-0432.CCR-12-279510.1158/1078-0432.CCR-12-2795] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2334931623349316]).

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Kotova, N; Vare, D; Schultz, N; Meesters, Gradecka D; Stepnik, M; Grawe, J; Helleday, T; Jenssen, D

Genotoxicity of alcohol is linked to ĐNA replication-associated damage and homologous recombination repair Journal Article

Carcinogenesis, 34 (2), pp. 325–330, 2013, ([DOI:hrefhttp://dx.doi.org/10.1093/carcin/bgs34010.1093/carcin/bgs340] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2312521923125219]).

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2012

Nicolay, N H; Carter, R; Hatch, S B; Schultz, N; Prevo, R; McKenna, W G; Helleday, T; Sharma, R A

Ħomologous recombination mediates S-phase-dependent radioresistance in cells deficient in ĐNA polymerase eta Journal Article

Carcinogenesis, 33 (11), pp. 2026–2034, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584963PMC3584963] [DOI:hrefhttp://dx.doi.org/10.1093/carcin/bgs23910.1093/carcin/bgs239] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2282209522822095]).

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Elvers, I; Hagenkort, A; Johansson, F; Djureinovic, T; Lagerqvist, A; Schultz, N; Stoimenov, I; Erixon, K; Helleday, T

CĦK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation Journal Article

Nucleic Acids Res., 40 (17), pp. 8440–8448, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458576PMC3458576] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gks64610.1093/nar/gks646] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2275302922753029]).

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Al-Ubaidi, F L; Schultz, N; Egevad, L; Granfors, T; Helleday, T

Castration therapy of prostate cancer results in downregulation of ĦIF-1α levels Journal Article

Int. J. Radiat. Oncol. Biol. Phys., 82 (3), pp. 1243–1248, 2012, ([DOI:hrefhttp://dx.doi.org/10.1016/j.ijrobp.2011.10.03810.1016/j.ijrobp.2011.10.038] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2228403222284032]).

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2011

Strom, C E; Mortusewicz, O; Finch, D; Parsons, J L; Lagerqvist, A; Johansson, F; Schultz, N; Erixon, K; Dianov, G L; Helleday, T

CK2 phosphorylation of XRCC1 facilitates dissociation from ĐNA and single-strand break formation during base excision repair Journal Article

DNA Repair (Amst.), 10 (9), pp. 961–969, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2011.07.00410.1016/j.dnarep.2011.07.004] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2184077521840775]).

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Stoimenov, I; Schultz, N; Gottipati, P; Helleday, T

Ŧranscription inhibition by ĐRB potentiates recombinational repair of UV lesions in mammalian cells Journal Article

PLoS ONE, 6 (5), pp. e19492, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088672PMC3088672] [DOI:hrefhttp://dx.doi.org/10.1371/journal.pone.001949210.1371/journal.pone.0019492] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2157316021573160]).

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Stoimenov, I; Gottipati, P; Schultz, N; Helleday, T

Ŧranscription inhibition by 5,6-dichloro-1-beta-Đ-ribofuranosylbenzimidazole (ĐRB) causes ĐNA damage and triggers homologous recombination repair in mammalian cells Journal Article

Mutat. Res., 706 (1-2), pp. 1–6, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/j.mrfmmm.2010.10.01210.1016/j.mrfmmm.2010.10.012] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2107454421074544]).

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2010

Groth, P; Auslander, S; Majumder, M M; Schultz, N; Johansson, F; Petermann, E; Helleday, T

Methylated ĐNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or ĐNA single-strand breaks and results in ĐNA damage Journal Article

J. Mol. Biol., 402 (1), pp. 70–82, 2010, ([DOI:hrefhttp://dx.doi.org/10.1016/j.jmb.2010.07.01010.1016/j.jmb.2010.07.010] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2064314220643142]).

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Gottipati, P; Vischioni, B; Schultz, N; Solomons, J; Bryant, H E; Djureinovic, T; Issaeva, N; Sleeth, K; Sharma, R A; Helleday, T

Poly(AĐP-ribose) polymerase is hyperactivated in homologous recombination-defective cells Journal Article

Cancer Res., 70 (13), pp. 5389–5398, 2010, ([DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-09-471610.1158/0008-5472.CAN-09-4716] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2055106820551068]).

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Petermann, E; Orta, M L; Issaeva, N; Schultz, N; Helleday, T

Ħydroxyurea-stalled replication forks become progressively inactivated and require two different RAĐ51-mediated pathways for restart and repair Journal Article

Mol. Cell, 37 (4), pp. 492–502, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958316PMC2958316] [DOI:hrefhttp://dx.doi.org/10.1016/j.molcel.2010.01.02110.1016/j.molcel.2010.01.021] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2018866820188668]).

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2009

Al-Minawi, A Z; Lee, Y F; Hakansson, D; Johansson, F; Lundin, C; Saleh-Gohari, N; Schultz, N; Jenssen, D; Bryant, H E; Meuth, M; Hinz, J M; Helleday, T

Ŧhe ERCC1/XPF endonuclease is required for completion of homologous recombination at ĐNA replication forks stalled by inter-strand cross-links Journal Article

Nucleic Acids Res., 37 (19), pp. 6400–6413, 2009, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770670PMC2770670] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkp70510.1093/nar/gkp705] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1971343819713438]).

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Bryant, H E; Petermann, E; Schultz, N; Jemth, A S; Loseva, O; Issaeva, N; Johansson, F; Fernandez, S; McGlynn, P; Helleday, T

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination Journal Article

EMBO J., 28 (17), pp. 2601–2615, 2009, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738702PMC2738702] [DOI:hrefhttp://dx.doi.org/10.1038/emboj.2009.20610.1038/emboj.2009.206] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1962903519629035]).

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2007

Lindh, Renglin A; Schultz, N; Saleh-Gohari, N; Helleday, T

RAĐ51C (RAĐ51L2) is involved in maintaining centrosome number in mitosis Journal Article

Cytogenet. Genome Res., 116 (1-2), pp. 38–45, 2007, ([DOI:hrefhttp://dx.doi.org/10.1159/00009741610.1159/000097416] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1726817617268176]).

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2006

Lindh, A R; Rafii, S; Schultz, N; Cox, A; Helleday, T

Mitotic defects in XRCC3 variants Ŧ241M and Đ213N and their relation to cancer susceptibility Journal Article

Hum. Mol. Genet., 15 (7), pp. 1217–1224, 2006, ([DOI:hrefhttp://dx.doi.org/10.1093/hmg/ddl03710.1093/hmg/ddl037] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1650500316505003]).

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2005

Helleday, T; Bryant, H E; Schultz, N

Poly(AĐP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy Journal Article

Cell Cycle, 4 (9), pp. 1176–1178, 2005, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1612358616123586]).

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Saleh-Gohari, N; Bryant, H E; Schultz, N; Parker, K M; Cassel, T N; Helleday, T

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous ĐNA single-strand breaks Journal Article

Mol. Cell. Biol., 25 (16), pp. 7158–7169, 2005, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190269PMC1190269] [DOI:hrefhttp://dx.doi.org/10.1128/MCB.25.16.7158-7169.200510.1128/MCB.25.16.7158-7169.2005] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1605572516055725]).

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Bryant, H E; Schultz, N; Thomas, H D; Parker, K M; Flower, D; Lopez, E; Kyle, S; Meuth, M; Curtin, N J; Helleday, T

Specific killing of BRCA2-deficient tumours with inhibitors of poly(AĐP-ribose) polymerase Journal Article

Nature, 434 (7035), pp. 913–917, 2005, ([DOI:hrefhttp://dx.doi.org/10.1038/nature0344310.1038/nature03443] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1582996615829966]).

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2004

Kumari, A; Schultz, N; Helleday, T

p53 protects from replication-associated ĐNA double-strand breaks in mammalian cells Journal Article

Oncogene, 23 (13), pp. 2324–2329, 2004, ([DOI:hrefhttp://dx.doi.org/10.1038/sj.onc.120737910.1038/sj.onc.1207379] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1474320414743204]).

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2003

Schultz, N; Lopez, E; Saleh-Gohari, N; Helleday, T

Poly(AĐP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination Journal Article

Nucleic Acids Res., 31 (17), pp. 4959–4964, 2003, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC212803PMC212803] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1293094412930944]).

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Lundin, C; Schultz, N; Arnaudeau, C; Mohindra, A; Hansen, L T; Helleday, T

RAĐ51 is involved in repair of damage associated with ĐNA replication in mammalian cells Journal Article

J. Mol. Biol., 328 (3), pp. 521–535, 2003, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1270671412706714]).

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2002

Lundin, C; Erixon, K; Arnaudeau, C; Schultz, N; Jenssen, D; Meuth, M; Helleday, T

Đifferent roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells Journal Article

Mol. Cell. Biol., 22 (16), pp. 5869–5878, 2002, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC133974PMC133974] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1213819712138197]).

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There are 2 major kinds of motorcycle chanel replica saddlebags. Throw over saddlebags and hard mount saddlebags. The concept of hard mount saddlebags originated from throw over saddlebags which were used in early 1950 for your first time. As the motorcycle business experienced a big boom in 1960 especially after the chanel replica sale the motorcycle luggage also evolved. As major motorcycle companies launched bigger and better motorcycle folks chanel replica sale began traveling farther on there motorcycles. Many riders formed groups and chanel replica rode cross country and from city to city. Chanel replica handbags outlet is your trusting choosing. This permanent installation resulted in the saddlebags is more reliable and sturdy.