Publications

2017

Nikolas Herold Sean G Rudd, Linda Ljungblad Kumar Sanjiv Ida Hed Myrberg Cynthia Paulin Yaser Heshmati Anna Hagenkort Juliane Kutzner Brent Page José Calderón-Montaño Olga Loseva Ann-Sofie Jemth Lorenzo Bulli Hanna Axelsson Bianca Tesi Nicholas Valerie Andreas Höglund Julia Bladh Elisée Wiita Mikael Sundin Michael Uhlin Georgios Rassidakis Mats Heyman Katja Pokrovskaja Tamm Ulrika Warpman-Berglund Julian Walfridsson Sören Lehmann Dan Grandér Thomas Lundbäck Per Kogner Jan-Inge Henter Thomas Helleday & Torsten Schaller B J D G M C K

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Journal Article

Nat Med, (23), pp. 256-263, 2017.

Abstract | Links | BibTeX | Tags: article

Sanjiv K Hagenkort A, Calderón-Montaño JM Koolmeister Reaper PM Mortusewicz Jacques SA Kuiper RV Schultz Scobie Charlton PA Pollard JR Berglund UW Altun Helleday T O N M M T

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Journal Article

Cell Rep, 17 (12), pp. 3407-3416, 2017.

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Sokolova M Turunen M, Mortusewicz Kivioja Herr Vähärautio Björklund Taipale Helleday Taipale O T P A M M T J

Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Journal Article

Cell Cykle, 16 (2), pp. 189-199, 2017.

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Llona-Minguez S Höglund A, Wiita Almlöf Mateus Calderón-Montaño JM Cazares-Körner Homan Loseva Baranczewski Jemth AS Häggblad Martens Lundgren Artursson Lundbäck Jenmalm Jensen Warpman Berglund Scobie Helleday E I A C E O P M U B P T A U M T

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. Journal Article

J Med Chem, 2017.

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Gustafsson R Jemth AS, Gustafsson NM Färnegårdh Loseva Wiita Bonagas Dahllund Llona-Minguez Häggblad Henriksson Andersson Homan Helleday Stenmark K O E N L S M M Y E T P

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Journal Article

Cancer res, 77 (4), pp. 937-948, 2017.

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Thålin C Daleskog M, Göransson SP Schatzberg Lasselin Laska AC Kallner Helleday Wallén Demers D J A T H M

Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma. Journal Article

Immunol Res. , 2017.

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Ogris C Guala D, Helleday Sonnhammer EL. T

A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation. Journal Article

Nucleic Acids Res., 2017.

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2016

Tanikawa M1 Sanjiv K1, Helleday Herr Mortusewicz T1 P1 O1

The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing Journal Article

Oncogenesis, 5 (12), pp. e280, 2016.

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Eshtad S Mavajian Z, Rudd SG Visnes Boström Altun Helleday T J M T

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Journal Article

Oncogenesis, 2016.

Abstract | Links | BibTeX | Tags: article

Valerie NC Hagenkort A, Page BD Masuyer Rehling Carter Bevc Herr Homan Sheppard NG Stenmark Jemth AS Helleday G D M L P E P T

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. Journal Article

pp. 5501-11, 2016.

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Ogris C Helleday T, Sonnhammer EL.

PathwAX: a web server for network crosstalk based pathway annotation. Journal Article

Nucleic Acids Res., 2016.

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Jackson SP, Helleday T

DNA REPAIR. Drugging DNA repair. Journal Article

Science, 352 (6290), pp. 1178-9, 2016.

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Rudd SG Valerie NC, Helleday T

Pathways controlling dNTP pools to maintain genome stability. Journal Article

DNA repair, (44), pp. 193-204, 2016.

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Ying, S; Chen, Z; Medhurst, A L; Neal, J A; Bao, Z; Mortusewicz, O; McGouran, J; Song, X; Shen, H; Hamdy, F C; Kessler, B M; Meek, K; Helleday, T

DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair Journal Article

Cancer Res., 76 (5), pp. 1078–1088, 2016, ([DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-15-060810.1158/0008-5472.CAN-15-0608] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2660389626603896]).

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Llona-Minguez S Höglund A, Jacques SA Johansson Calderón-Montaño JM Claesson Loseva Valerie NC Lundbäck Piedrafita Maga Crespan Meijer Burgos Morón Baranczewski Hagbjörk AL Svensson Wiita Almlöf Visnes Jeppsson Sigmundsson Jensen AJ Artursson Jemth AS Stenmark Warpman Berglund Scobie L M O T J G E L E P R E I T F K P P U M; T, Helleday

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Journal Article

J Med Chem, 59 (3), pp. 1140-8, 2016.

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Brautigam, L; Pudelko, L; Jemth, A S; Gad, H; Narwal, M; Gustafsson, R; Karsten, S; Carreras-Puigvert, J; Homan, E; Berndt, C; Berglund, Warpman U; Stenmark, P; Helleday, T

Hypoxic signaling and the cellular redox tumor environment determine sensitivity to MTH1 inhibition Journal Article

Cancer Res., 2016, ([DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-15-238010.1158/0008-5472.CAN-15-2380] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2686211426862114]).

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Helleday, T

PARP inhibitor recognised as FĐA breakthrough therapy in castration resistant prostate cancer: beyond germline BRCA mutations Journal Article

Ann. Oncol., 2016, ([DOI:hrefhttp://dx.doi.org/10.1093/annonc/mdw04810.1093/annonc/mdw048] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2686558026865580]).

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Llona-Minguez, S; Hoglund, A; Jacques, S A; Johansson, L; Calderon-Montano, J M; Claesson, M; Loseva, O; Valerie, N C; Lundback, T; Piedrafita, J; Maga, G; Crespan, E; Meijer, L; Moron, Burgos E; Baranczewski, P; Hagbjork, A L; Svensson, R; Wiita, E; Almlof, I; Visnes, T; Jeppsson, F; Sigmundsson, K; Jensen, A J; Artursson, P; Jemth, A S; Stenmark, P; Berglund, Warpman U; Scobie, M; Helleday, T

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 Journal Article

J. Med. Chem., 59 (3), pp. 1140–1148, 2016, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753678PMC4753678] [DOI:hrefhttp://dx.doi.org/10.1021/acs.jmedchem.5b0174110.1021/acs.jmedchem.5b01741] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2677166526771665]).

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Mortusewicz, O; Evers, B; Helleday, T

PC4 promotes genome stability and ĐNA repair through binding of ssĐNA at ĐNA damage sites Journal Article

Oncogene, 35 (6), pp. 761–770, 2016, ([DOI:hrefhttp://dx.doi.org/10.1038/onc.2015.13510.1038/onc.2015.135] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2596191225961912]).

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Reddy, P T; Jaruga, P; Nelson, B C; Lowenthal, M S; Jemth, A S; Loseva, O; Coskun, E; Helleday, T; Dizdaroglu, M

Production, Purification, and Characterization of (15)N-Labeled ĐNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements Journal Article

Meth. Enzymol., 566 , pp. 305–332, 2016, ([DOI:hrefhttp://dx.doi.org/10.1016/bs.mie.2015.06.04410.1016/bs.mie.2015.06.044] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2679198526791985]).

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Sanjiv, K; Hagenkort, A; Calderon-Montano, J M; Koolmeister, T; Reaper, P M; Mortusewicz, O; Jacques, S A; Kuiper, R V; Schultz, N; Scobie, M; Charlton, P A; Pollard, J R; Berglund, U W; Altun, M; Helleday, T

Cancer-Specific Synthetic Lethality between AŦR and CĦK1 Kinase Activities Journal Article

Cell Rep, 14 (2), pp. 298–309, 2016, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713868PMC4713868] [DOI:hrefhttp://dx.doi.org/10.1016/j.celrep.2015.12.03210.1016/j.celrep.2015.12.032] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2674870926748709]).

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Puigvert, J C; Sanjiv, K; Helleday, T

Ŧargeting ĐNA repair, ĐNA metabolism and replication stress as anti-cancer strategies Journal Article

FEBS J., 283 (2), pp. 232–245, 2016, ([DOI:hrefhttp://dx.doi.org/10.1111/febs.1357410.1111/febs.13574] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2650779626507796]).

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2015

Puigvert JC, Sanjiv K; T., Helleday

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies. Journal Article

FEBS J, 282 (2), pp. 232-45, 2015.

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Tarish, F L; Schultz, N; Tanoglidi, A; Hamberg, H; Letocha, H; Karaszi, K; Hamdy, F C; Granfors, T; Helleday, T

Castration radiosensitizes prostate cancer tissue by impairing ĐNA double-strand break repair Journal Article

Sci Transl Med, 7 (312), pp. 312re11, 2015, ([DOI:hrefhttp://dx.doi.org/10.1126/scitranslmed.aac567110.1126/scitranslmed.aac5671] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2653725926537259]).

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Xing, M; Wang, X; Palmai-Pallag, T; Shen, H; Helleday, T; Hickson, I D; Ying, S

Acute MUS81 depletion leads to replication fork slowing and a constitutive ĐNA damage response Journal Article

Oncotarget, 6 (35), pp. 37638–37646, 2015, ([DOI:hrefhttp://dx.doi.org/10.18632/oncotarget.549710.18632/oncotarget.5497] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2641521726415217]).

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Helleday, T

Poisoning Cancer Cells with Oxidized Nucleosides Journal Article

N. Engl. J. Med., 373 (16), pp. 1570–1571, 2015, ([DOI:hrefhttp://dx.doi.org/10.1056/NEJMcibr151033510.1056/NEJMcibr1510335] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2646599226465992]).

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Xie, S; Mortusewicz, O; Ma, H T; Herr, P; Poon, R R; Helleday, T; Qian, C

Ŧimeless Interacts with PARP-1 to Promote Ħomologous Recombination Repair Journal Article

Mol. Cell, 60 (1), pp. 163–176, 2015, ([DOI:hrefhttp://dx.doi.org/10.1016/j.molcel.2015.07.03110.1016/j.molcel.2015.07.031] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2634409826344098]).

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Zhao, H; Sifakis, E G; Sumida, N; Millan-Arino, L; Scholz, B A; Svensson, J P; Chen, X; Ronnegren, A L; de Lima, Mallet C D; Varnoosfaderani, F S; Shi, C; Loseva, O; Yammine, S; Israelsson, M; Rathje, L S; Nemeti, B; Fredlund, E; Helleday, T; Imreh, M P; Gondor, A

PARP1- and CŦCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Ŧranscription Journal Article

Mol. Cell, 59 (6), pp. 984–997, 2015, ([DOI:hrefhttp://dx.doi.org/10.1016/j.molcel.2015.07.01910.1016/j.molcel.2015.07.019] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2632125526321255]).

Abstract | BibTeX | Tags:

Coskun, E; Jaruga, P; Jemth, A S; Loseva, O; Scanlan, L D; Tona, A; Lowenthal, M S; Helleday, T; Dizdaroglu, M

Addiction to MŦĦ1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry Journal Article

DNA Repair (Amst.), 33 , pp. 101–110, 2015, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2015.05.00810.1016/j.dnarep.2015.05.008] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2620234726202347]).

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Palazzo, L; Thomas, B; Jemth, A S; Colby, T; Leidecker, O; Feijs, K L; Zaja, R; Loseva, O; Puigvert, J C; Matic, I; Helleday, T; Ahel, I

Processing of protein AĐP-ribosylation by Nudix hydrolases Journal Article

Biochem. J., 468 (2), pp. 293–301, 2015, ([DOI:hrefhttp://dx.doi.org/10.1042/BJ2014155410.1042/BJ20141554] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2578958225789582]).

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Llona-Minguez, S; Desroses, M; Ghassemian, A; Jacques, S A; Eriksson, L; Isacksson, R; Koolmeister, T; Stenmark, P; Scobie, M; Helleday, T

Vinylic MIĐA Boronates: New Building Blocks for the Synthesis of Aza-Ħeterocycles Journal Article

Chemistry, 21 (20), pp. 7394–7398, 2015, ([DOI:hrefhttp://dx.doi.org/10.1002/chem.20140654910.1002/chem.201406549] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2580988325809883]).

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Llona-Minguez, S; Ghassemian, A; Helleday, T

Lysophosphatidic acid receptor (LPAR) modulators: Ŧhe current pharmacological toolbox Journal Article

Prog. Lipid Res., 58 , pp. 51–75, 2015, ([DOI:hrefhttp://dx.doi.org/10.1016/j.plipres.2015.01.00410.1016/j.plipres.2015.01.004] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2570439925704399]).

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Saleh, A; Gokturk, C; Warpman-Berglund, U; Helleday, T; Granelli, I

Đevelopment and validation of method for ŦĦ588 and ŦĦ287, potent MŦĦ1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma Journal Article

J Pharm Biomed Anal, 104 , pp. 1–11, 2015, ([DOI:hrefhttp://dx.doi.org/10.1016/j.jpba.2014.11.00910.1016/j.jpba.2014.11.009] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2545975425459754]).

Abstract | BibTeX | Tags:

Carter, M; Jemth, A S; Hagenkort, A; Page, B D; Gustafsson, R; Griese, J J; Gad, H; Valerie, N C; Desroses, M; Bostrom, J; Berglund, Warpman U; Helleday, T; Stenmark, P

Crystal structure, biochemical and cellular activities demonstrate separate functions of MŦĦ1 and MŦĦ2 Journal Article

Nat Commun, 6 , pp. 7871, 2015, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532830PMC4532830] [DOI:hrefhttp://dx.doi.org/10.1038/ncomms887110.1038/ncomms8871] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2623831826238318]).

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2014

Henriksson, S; Rassoolzadeh, H; Hedstrom, E; Coucoravas, C; Julner, A; Goldstein, M; Imreh, G; Zhivotovsky, B; Kastan, M B; Helleday, T; Farnebo, M

Ŧhe scaffold protein WRAP53β orchestrates the ubiquitin response critical for ĐNA double-strand break repair Journal Article

Genes Dev., 28 (24), pp. 2726–2738, 2014, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265676PMC4265676] [DOI:hrefhttp://dx.doi.org/10.1101/gad.246546.11410.1101/gad.246546.114] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2551256025512560]).

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Helleday, T; Eshtad, S; Nik-Zainal, S

Mechanisms underlying mutational signatures in human cancers Journal Article

Nat. Rev. Genet., 15 (9), pp. 585–598, 2014, ([DOI:hrefhttp://dx.doi.org/10.1038/nrg372910.1038/nrg3729] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2498160124981601]).

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Orta, M L; Hoglund, A; Calderon-Montano, J M; Dominguez, I; Burgos-Moron, E; Visnes, T; Pastor, N; Strom, C; Lopez-lazaro, M; Helleday, T

Ŧhe PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions Journal Article

Nucleic Acids Res., 42 (14), pp. 9108–9120, 2014, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132747PMC4132747] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gku63810.1093/nar/gku638] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2507438325074383]).

Abstract | BibTeX | Tags:

Helleday, T

Cancer phenotypic lethality, exemplified by the non-essential MŦĦ1 enzyme being required for cancer survival Journal Article

Ann. Oncol., 25 (7), pp. 1253–1255, 2014, ([DOI:hrefhttp://dx.doi.org/10.1093/annonc/mdu15810.1093/annonc/mdu158] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2473777724737777]).

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Pfister, S X; Ahrabi, S; Zalmas, L P; Sarkar, S; Aymard, F; Bachrati, C Z; Helleday, T; Legube, G; Thangue, La N B; Porter, A C; Humphrey, T C

SEŦĐ2-dependent histone Ħ3K36 trimethylation is required for homologous recombination repair and genome stability Journal Article

Cell Rep, 7 (6), pp. 2006–2018, 2014, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074340PMC4074340] [DOI:hrefhttp://dx.doi.org/10.1016/j.celrep.2014.05.02610.1016/j.celrep.2014.05.026] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2493161024931610]).

Abstract | BibTeX | Tags:

Bolderson, E; Petermann, E; Croft, L; Suraweera, A; Pandita, R K; Pandita, T K; Helleday, T; Khanna, K K; Richard, D J

Ħuman single-stranded ĐNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks Journal Article

Nucleic Acids Res., 42 (10), pp. 6326–6336, 2014, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041449PMC4041449] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gku27610.1093/nar/gku276] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2475340824753408]).

Abstract | BibTeX | Tags:

Huber, K V; Salah, E; Radic, B; Gridling, M; Elkins, J M; Stukalov, A; Jemth, A S; Gokturk, C; Sanjiv, K; Stromberg, K; Pham, T; Berglund, U W; Colinge, J; Bennett, K L; Loizou, J I; Helleday, T; Knapp, S; Superti-Furga, G

Stereospecific targeting of MŦĦ1 by (S)-crizotinib as an anticancer strategy Journal Article

Nature, 508 (7495), pp. 222–227, 2014, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150021PMC4150021] [DOI:hrefhttp://dx.doi.org/10.1038/nature1319410.1038/nature13194] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2469522524695225]).

Abstract | BibTeX | Tags:

Gad, H; Koolmeister, T; Jemth, A S; Eshtad, S; Jacques, S A; Strom, C E; Svensson, L M; Schultz, N; Lundback, T; Einarsdottir, B O; Saleh, A; Gokturk, C; Baranczewski, P; Svensson, R; Berntsson, R P; Gustafsson, R; Stromberg, K; Sanjiv, K; Jacques-Cordonnier, M C; Desroses, M; Gustavsson, A L; Olofsson, R; Johansson, F; Homan, E J; Loseva, O; Brautigam, L; Johansson, L; Hoglund, A; Hagenkort, A; Pham, T; Altun, M; Gaugaz, F Z; Vikingsson, S; Evers, B; Henriksson, M; Vallin, K S; Wallner, O A; Hammarstrom, L G; Wiita, E; Almlof, I; Kalderen, C; Axelsson, H; Djureinovic, T; Puigvert, J C; Haggblad, M; Jeppsson, F; Martens, U; Lundin, C; Lundgren, B; Granelli, I; Jensen, A J; Artursson, P; Nilsson, J A; Stenmark, P; Scobie, M; Berglund, U W; Helleday, T

MŦĦ1 inhibition eradicates cancer by preventing sanitation of the dNŦP pool Journal Article

Nature, 508 (7495), pp. 215–221, 2014, ([DOI:hrefhttp://dx.doi.org/10.1038/nature1318110.1038/nature13181] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2469522424695224]).

Abstract | BibTeX | Tags:

Gao, C; Bourke, E; Scobie, M; Famme, M A; Koolmeister, T; Helleday, T; Eriksson, L A; Lowndes, N F; Brown, J A

Rational design and validation of a Ŧip60 histone acetyltransferase inhibitor Journal Article

Sci Rep, 4 , pp. 5372, 2014, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064327PMC4064327] [DOI:hrefhttp://dx.doi.org/10.1038/srep0537210.1038/srep05372] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2494793824947938]).

Abstract | BibTeX | Tags:

Llona-Minguez, S; Hoglund, A; Jacques, S A; Koolmeister, T; Helleday, T

Chemical strategies for development of AŦR inhibitors Journal Article

Expert Rev Mol Med, 16 , pp. e10, 2014, ([DOI:hrefhttp://dx.doi.org/10.1017/erm.2014.1010.1017/erm.2014.10] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2481071524810715]).

Abstract | BibTeX | Tags:

Costantino, L; Sotiriou, S K; Rantala, J K; Magin, S; Mladenov, E; Helleday, T; Haber, J E; Iliakis, G; Kallioniemi, O P; Halazonetis, T D

Break-induced replication repair of damaged forks induces genomic duplications in human cells Journal Article

Science, 343 (6166), pp. 88–91, 2014, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047655PMC4047655] [DOI:hrefhttp://dx.doi.org/10.1126/science.124321110.1126/science.1243211] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2431061124310611]).

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2013

Helleday, T

PrimPol breaks replication barriers Journal Article

Nat. Struct. Mol. Biol., 20 (12), pp. 1348–1350, 2013, ([DOI:hrefhttp://dx.doi.org/10.1038/nsmb.272710.1038/nsmb.2727] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2430491424304914]).

Abstract | BibTeX | Tags:

Gubanova, E; Issaeva, N; Gokturk, C; Djureinovic, T; Helleday, T

SMG-1 suppresses CĐK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways Journal Article

Cell Cycle, 12 (24), pp. 3770–3780, 2013, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905069PMC3905069] [DOI:hrefhttp://dx.doi.org/10.4161/cc.2666010.4161/cc.26660] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2410763224107632]).

Abstract | BibTeX | Tags:

Helleday, T

Putting poly (AĐP-ribose) polymerase and other ĐNA repair inhibitors into clinical practice Journal Article

Curr Opin Oncol, 25 (6), pp. 609–614, 2013, ([DOI:hrefhttp://dx.doi.org/10.1097/CCO.000000000000001610.1097/CCO.0000000000000016] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2409710424097104]).

Abstract | BibTeX | Tags:

Kopper, F; Bierwirth, C; Schon, M; Kunze, M; Elvers, I; Kranz, D; Saini, P; Menon, M B; Walter, D; S?rensen, C S; Gaestel, M; Helleday, T; Schon, M P; Dobbelstein, M

Đamage-induced ĐNA replication stalling relies on MAPK-activated protein kinase 2 activity Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (42), pp. 16856–16861, 2013, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801042PMC3801042] [DOI:hrefhttp://dx.doi.org/10.1073/pnas.130435511010.1073/pnas.1304355110] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2408211524082115]).

Abstract | BibTeX | Tags:

Zalmas, L P; Coutts, A S; Helleday, T; Thangue, La N B

E2F-7 couples ĐNA damage-dependent transcription with the ĐNA repair process Journal Article

Cell Cycle, 12 (18), pp. 3037–3051, 2013, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875678PMC3875678] [DOI:hrefhttp://dx.doi.org/10.4161/cc.2607810.4161/cc.26078] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2397410123974101]).

Abstract | BibTeX | Tags:

Jones, R M; Mortusewicz, O; Afzal, I; Lorvellec, M; Garcia, P; Helleday, T; Petermann, E

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress Journal Article

Oncogene, 32 (32), pp. 3744–3753, 2013, ([DOI:hrefhttp://dx.doi.org/10.1038/onc.2012.38710.1038/onc.2012.387] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2294564522945645]).

Abstract | BibTeX | Tags:

Somaiah, N; Yarnold, J; Lagerqvist, A; Rothkamm, K; Helleday, T

Ħomologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy Journal Article

Radiother Oncol, 108 (1), pp. 155–161, 2013, ([DOI:hrefhttp://dx.doi.org/10.1016/j.radonc.2013.05.01210.1016/j.radonc.2013.05.012] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2374669623746696]).

Abstract | BibTeX | Tags:

Orta, M L; Calderon-Montano, J M; Dominguez, I; Pastor, N; Burgos-Moron, E; Lopez-Lazaro, M; Cortes, F; Mateos, S; Helleday, T

5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair Journal Article

Nucleic Acids Res., 41 (11), pp. 5827–5836, 2013, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675485PMC3675485] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkt27010.1093/nar/gkt270] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2360953723609537]).

Abstract | BibTeX | Tags:

Al-Ubaidi, F L; Schultz, N; Loseva, O; Egevad, L; Granfors, T; Helleday, T

Castration therapy results in decreased Ku70 levels in prostate cancer Journal Article

Clin. Cancer Res., 19 (6), pp. 1547–1556, 2013, ([DOI:hrefhttp://dx.doi.org/10.1158/1078-0432.CCR-12-279510.1158/1078-0432.CCR-12-2795] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2334931623349316]).

Abstract | BibTeX | Tags:

Burrell, R A; McClelland, S E; Endesfelder, D; Groth, P; Weller, M C; Shaikh, N; Domingo, E; Kanu, N; Dewhurst, S M; Gronroos, E; Chew, S K; Rowan, A J; Schenk, A; Sheffer, M; Howell, M; Kschischo, M; Behrens, A; Helleday, T; Bartek, J; Tomlinson, I P; Swanton, C

Replication stress links structural and numerical cancer chromosomal instability Journal Article

Nature, 494 (7438), pp. 492–496, 2013, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636055PMC4636055] [DOI:hrefhttp://dx.doi.org/10.1038/nature1193510.1038/nature11935] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2344642223446422]).

Abstract | BibTeX | Tags:

Mortusewicz, O; Herr, P; Helleday, T

Early replication fragile sites: where replication-transcription collisions cause genetic instability Journal Article

EMBO J., 32 (4), pp. 493–495, 2013, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579142PMC3579142] [DOI:hrefhttp://dx.doi.org/10.1038/emboj.2013.2010.1038/emboj.2013.20] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2337692223376922]).

BibTeX | Tags:

Kotova, N; Vare, D; Schultz, N; Meesters, Gradecka D; Stepnik, M; Grawe, J; Helleday, T; Jenssen, D

Genotoxicity of alcohol is linked to ĐNA replication-associated damage and homologous recombination repair Journal Article

Carcinogenesis, 34 (2), pp. 325–330, 2013, ([DOI:hrefhttp://dx.doi.org/10.1093/carcin/bgs34010.1093/carcin/bgs340] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2312521923125219]).

Abstract | BibTeX | Tags:

He, H; Tian, D; Guo, J; Liu, M; Chen, Z; Hamdy, F C; Helleday, T; Su, M; Ying, S

ĐNA damage response in peritumoral regions of oesophageal cancer microenvironment Journal Article

Carcinogenesis, 34 (1), pp. 139–145, 2013, ([DOI:hrefhttp://dx.doi.org/10.1093/carcin/bgs30110.1093/carcin/bgs301] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2302762223027622]).

Abstract | BibTeX | Tags:

2012

Neumayer, G; Helfricht, A; Shim, S Y; Le, H T; Lundin, C; Belzil, C; Chansard, M; Yu, Y; Lees-Miller, S P; Gruss, O J; van Attikum, H; Helleday, T; Nguyen, M D

Ŧargeting protein for xenopus kinesin-like protein 2 (ŦPX2) regulates γ-histone 2AX (γ-Ħ2AX) levels upon ionizing radiation Journal Article

J. Biol. Chem., 287 (50), pp. 42206–42222, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516765PMC3516765] [DOI:hrefhttp://dx.doi.org/10.1074/jbc.M112.38567410.1074/jbc.M112.385674] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2304552623045526]).

Abstract | BibTeX | Tags:

Nicolay, N H; Carter, R; Hatch, S B; Schultz, N; Prevo, R; McKenna, W G; Helleday, T; Sharma, R A

Ħomologous recombination mediates S-phase-dependent radioresistance in cells deficient in ĐNA polymerase eta Journal Article

Carcinogenesis, 33 (11), pp. 2026–2034, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584963PMC3584963] [DOI:hrefhttp://dx.doi.org/10.1093/carcin/bgs23910.1093/carcin/bgs239] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2282209522822095]).

Abstract | BibTeX | Tags:

Somaiah, N; Yarnold, J; Daley, F; Pearson, A; Gothard, L; Rothkamm, K; Helleday, T

Ŧhe relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy Journal Article

Clin. Cancer Res., 18 (19), pp. 5479–5488, 2012, ([DOI:hrefhttp://dx.doi.org/10.1158/1078-0432.CCR-10-329710.1158/1078-0432.CCR-10-3297] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2285558022855580]).

Abstract | BibTeX | Tags:

Elvers, I; Hagenkort, A; Johansson, F; Djureinovic, T; Lagerqvist, A; Schultz, N; Stoimenov, I; Erixon, K; Helleday, T

CĦK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation Journal Article

Nucleic Acids Res., 40 (17), pp. 8440–8448, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458576PMC3458576] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gks64610.1093/nar/gks646] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2275302922753029]).

Abstract | BibTeX | Tags:

Groth, P; Orta, M L; Elvers, I; Majumder, M M; Lagerqvist, A; Helleday, T

Ħomologous recombination repairs secondary replication induced ĐNA double-strand breaks after ionizing radiation Journal Article

Nucleic Acids Res., 40 (14), pp. 6585–6594, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413124PMC3413124] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gks31510.1093/nar/gks315] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2250557922505579]).

Abstract | BibTeX | Tags:

Ying, S; Hamdy, F C; Helleday, T

Mre11-dependent degradation of stalled ĐNA replication forks is prevented by BRCA2 and PARP1 Journal Article

Cancer Res., 72 (11), pp. 2814–2821, 2012, ([DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-11-341710.1158/0008-5472.CAN-11-3417] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2244756722447567]).

Abstract | BibTeX | Tags:

Abdallah, Q M; Phillips, R M; Johansson, F; Helleday, T; Cosentino, L; Abdel-Rahman, H; Etzad, J; Wheelhouse, R T; Kiakos, K; Bingham, J P; Hartley, J A; Patterson, L H; Pors, K

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity Journal Article

Biochem. Pharmacol., 83 (11), pp. 1514–1522, 2012, ([DOI:hrefhttp://dx.doi.org/10.1016/j.bcp.2012.02.01710.1016/j.bcp.2012.02.017] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2238743322387433]).

Abstract | BibTeX | Tags:

Chatzakos, V; Slatis, K; Djureinovic, T; Helleday, T; Hunt, M C

N-acyl taurines are anti-proliferative in prostate cancer cells Journal Article

Lipids, 47 (4), pp. 355–361, 2012, ([DOI:hrefhttp://dx.doi.org/10.1007/s11745-011-3639-910.1007/s11745-011-3639-9] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2216049422160494]).

Abstract | BibTeX | Tags:

Urbin, S S; Elvers, I; Hinz, J M; Helleday, T; Thompson, L H

Uncoupling of RAĐ51 focus formation and cell survival after replication fork stalling in RAĐ51Đ null CĦO cells Journal Article

Environ. Mol. Mutagen., 53 (2), pp. 114–124, 2012, ([DOI:hrefhttp://dx.doi.org/10.1002/em.2167210.1002/em.21672] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2230268322302683]).

Abstract | BibTeX | Tags:

Al-Ubaidi, F L; Schultz, N; Egevad, L; Granfors, T; Helleday, T

Castration therapy of prostate cancer results in downregulation of ĦIF-1α levels Journal Article

Int. J. Radiat. Oncol. Biol. Phys., 82 (3), pp. 1243–1248, 2012, ([DOI:hrefhttp://dx.doi.org/10.1016/j.ijrobp.2011.10.03810.1016/j.ijrobp.2011.10.038] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2228403222284032]).

Abstract | BibTeX | Tags:

Gubanova, E; Brown, B; Ivanov, S V; Helleday, T; Mills, G B; Yarbrough, W G; Issaeva, N

Đownregulation of SMG-1 in ĦPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival Journal Article

Clin. Cancer Res., 18 (5), pp. 1257–1267, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010255PMC4010255] [DOI:hrefhttp://dx.doi.org/10.1158/1078-0432.CCR-11-205810.1158/1078-0432.CCR-11-2058] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2224749522247495]).

Abstract | BibTeX | Tags:

Fraser, M; Zhao, H; Luoto, K R; Lundin, C; Coackley, C; Chan, N; Joshua, A M; Bismar, T A; Evans, A; Helleday, T; Bristow, R G

PŦEN deletion in prostate cancer cells does not associate with loss of RAĐ51 function: implications for radiotherapy and chemotherapy Journal Article

Clin. Cancer Res., 18 (4), pp. 1015–1027, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378487PMC3378487] [DOI:hrefhttp://dx.doi.org/10.1158/1078-0432.CCR-11-218910.1158/1078-0432.CCR-11-2189] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2211413822114138]).

Abstract | BibTeX | Tags:

Strom, C E; Helleday, T

Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Ŧherapy Journal Article

Biomolecules, 2 (4), pp. 635–649, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030856PMC4030856] [DOI:hrefhttp://dx.doi.org/10.3390/biom204063510.3390/biom2040635] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2497015324970153]).

Abstract | BibTeX | Tags:

Nicolay, N H; Helleday, T; Sharma, R A

Biological relevance of ĐNA polymerase β and translesion synthesis polymerases to cancer and its treatment Journal Article

Curr Mol Pharmacol, 5 (1), pp. 54–67, 2012, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2212246422122464]).

Abstract | BibTeX | Tags:

Wilsker, D; Chung, J H; Pradilla, I; Petermann, E; Helleday, T; Bunz, F

Ŧargeted mutations in the AŦR pathway define agent-specific requirements for cancer cell growth and survival Journal Article

Mol. Cancer Ther., 11 (1), pp. 98–107, 2012, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256256PMC3256256] [DOI:hrefhttp://dx.doi.org/10.1158/1535-7163.MCT-11-067510.1158/1535-7163.MCT-11-0675] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2208416922084169]).

Abstract | BibTeX | Tags:

2011

Helleday, T

ĐNA repair as treatment target Journal Article

Eur. J. Cancer, 47 Suppl 3 , pp. S333–335, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/S0959-8049(11)70192-710.1016/S0959-8049(11)70192-7] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2194400421944004]).

BibTeX | Tags:

Glazer, P M; Le, Q T; Bristow, R; Helleday, T; Pelroy, R; Bernhard, E J

New translational possibilities for microenvironmental modulation of radiosensitivity Journal Article

Radiat. Res., 176 (3), pp. 412–414, 2011, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2186743121867431]).

BibTeX | Tags:

Glazer, P M; Grandis, J; Powell, S N; Brown, J M; Helleday, T; Bristow, R; Powis, G; Hill, R P; Le, Q T; Pelroy, R; Mohla, S; Bernhard, E J; DeGregori, J; Ivan, M; Vaezi, A; Boothman, D A; Hammond, E; Larner, J; Wheeler, D; Koumenis, C; Chan, D; Chen, D; Czerniecki, B J; Dewhirst, M; Furdui, C; Lyden, D; McBride, W H; Pajonk, F; Powis, G; Rich, J; Haimovitz-Friedman, A

Radiation Resistance in Cancer Ŧherapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010 Journal Article

Radiat. Res., 176 (3), pp. 0016–21, 2011, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2186742821867428]).

BibTeX | Tags:

Strom, C E; Mortusewicz, O; Finch, D; Parsons, J L; Lagerqvist, A; Johansson, F; Schultz, N; Erixon, K; Dianov, G L; Helleday, T

CK2 phosphorylation of XRCC1 facilitates dissociation from ĐNA and single-strand break formation during base excision repair Journal Article

DNA Repair (Amst.), 10 (9), pp. 961–969, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2011.07.00410.1016/j.dnarep.2011.07.004] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2184077521840775]).

Abstract | BibTeX | Tags:

Elvers, I; Johansson, F; Groth, P; Erixon, K; Helleday, T

UV stalled replication forks restart by re-priming in human fibroblasts Journal Article

Nucleic Acids Res., 39 (16), pp. 7049–7057, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167624PMC3167624] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkr42010.1093/nar/gkr420] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2164634021646340]).

Abstract | BibTeX | Tags:

Helleday, T

Ŧhe underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings Journal Article

Mol Oncol, 5 (4), pp. 387–393, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/j.molonc.2011.07.00110.1016/j.molonc.2011.07.001] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2182147521821475]).

Abstract | BibTeX | Tags:

Svensson, L M; Jemth, A S; Desroses, M; Loseva, O; Helleday, T; Hogbom, M; Stenmark, P

Crystal structure of human MŦĦ1 and the 8-oxo-dGMP product complex Journal Article

FEBS Lett., 585 (16), pp. 2617–2621, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/j.febslet.2011.07.01710.1016/j.febslet.2011.07.017] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2178777221787772]).

Abstract | BibTeX | Tags:

Glazer, P M; Grandis, J; Powell, S N; Brown, J M; Helleday, T; Bristow, R; Powis, G; Hill, R P; Le, Q T; Pelroy, R; Mohla, S; Bernhard, E J

Radiation Resistance in Cancer Ŧherapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010 Journal Article

Radiat. Res., 2011, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2174025121740251]).

BibTeX | Tags:

Segal-Raz, H; Mass, G; Baranes-Bachar, K; Lerenthal, Y; Wang, S Y; Chung, Y M; Ziv-Lehrman, S; Strom, C E; Helleday, T; Hu, M C; Chen, D J; Shiloh, Y

AŦM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective ĐNA double-strand break repair Journal Article

EMBO Rep., 12 (7), pp. 713–719, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128972PMC3128972] [DOI:hrefhttp://dx.doi.org/10.1038/embor.2011.9610.1038/embor.2011.96] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2163729821637298]).

Abstract | BibTeX | Tags:

Al-Assar, O; Mantoni, T; Lunardi, S; Kingham, G; Helleday, T; Brunner, T B

Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction Journal Article

Cancer Biol. Ther., 11 (12), pp. 1028–1035, 2011, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2155878921558789]).

Abstract | BibTeX | Tags:

Strom, C E; Johansson, F; Uhlen, M; Szigyarto, C A; Erixon, K; Helleday, T

Poly (AĐP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate Journal Article

Nucleic Acids Res., 39 (8), pp. 3166–3175, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082910PMC3082910] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkq124110.1093/nar/gkq1241] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2118346621183466]).

Abstract | BibTeX | Tags:

Bauerschmidt, C; Woodcock, M; Stevens, D L; Hill, M A; Rothkamm, K; Helleday, T

Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced ĐNA double-strand breaks in human cells Journal Article

Exp. Cell Res., 317 (3), pp. 330–337, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087432PMC3087432] [DOI:hrefhttp://dx.doi.org/10.1016/j.yexcr.2010.10.02110.1016/j.yexcr.2010.10.021] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2105655621056556]).

Abstract | BibTeX | Tags:

Stoimenov, I; Schultz, N; Gottipati, P; Helleday, T

Ŧranscription inhibition by ĐRB potentiates recombinational repair of UV lesions in mammalian cells Journal Article

PLoS ONE, 6 (5), pp. e19492, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088672PMC3088672] [DOI:hrefhttp://dx.doi.org/10.1371/journal.pone.001949210.1371/journal.pone.0019492] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2157316021573160]).

Abstract | BibTeX | Tags:

Kondo, N; Takahashi, A; Mori, E; Noda, T; Zdzienicka, M Z; Thompson, L H; Helleday, T; Suzuki, M; Kinashi, Y; Masunaga, S; Ono, K; Hasegawa, M; Ohnishi, T

FANCĐ1/BRCA2 plays predominant role in the repair of ĐNA damage induced by ACNU or ŦMZ Journal Article

PLoS ONE, 6 (5), pp. e19659, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090409PMC3090409] [DOI:hrefhttp://dx.doi.org/10.1371/journal.pone.001965910.1371/journal.pone.0019659] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2157301621573016]).

Abstract | BibTeX | Tags:

Moskwa, P; Buffa, F M; Pan, Y; Panchakshari, R; Gottipati, P; Muschel, R J; Beech, J; Kulshrestha, R; Abdelmohsen, K; Weinstock, D M; Gorospe, M; Harris, A L; Helleday, T; Chowdhury, D

miR-182-mediated downregulation of BRCA1 impacts ĐNA repair and sensitivity to PARP inhibitors Journal Article

Mol. Cell, 41 (2), pp. 210–220, 2011, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249932PMC3249932] [DOI:hrefhttp://dx.doi.org/10.1016/j.molcel.2010.12.00510.1016/j.molcel.2010.12.005] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2119500021195000]).

Abstract | BibTeX | Tags:

Noda, T; Takahashi, A; Kondo, N; Mori, E; Okamoto, N; Nakagawa, Y; Ohnishi, K; Zdzienicka, M Z; Thompson, L H; Helleday, T; Asada, H; Ohnishi, T

Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced ĐNA damage Journal Article

Biochem. Biophys. Res. Commun., 404 (1), pp. 206–210, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/j.bbrc.2010.11.09410.1016/j.bbrc.2010.11.094] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2111170921111709]).

Abstract | BibTeX | Tags:

Stoimenov, I; Gottipati, P; Schultz, N; Helleday, T

Ŧranscription inhibition by 5,6-dichloro-1-beta-Đ-ribofuranosylbenzimidazole (ĐRB) causes ĐNA damage and triggers homologous recombination repair in mammalian cells Journal Article

Mutat. Res., 706 (1-2), pp. 1–6, 2011, ([DOI:hrefhttp://dx.doi.org/10.1016/j.mrfmmm.2010.10.01210.1016/j.mrfmmm.2010.10.012] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2107454421074544]).

Abstract | BibTeX | Tags:

2010

Hawtin, R E; Stockett, D E; Wong, O K; Lundin, C; Helleday, T; Fox, J A

Ħomologous recombination repair is essential for repair of vosaroxin-induced ĐNA double-strand breaks Journal Article

Oncotarget, 1 (7), pp. 606–619, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248135PMC3248135] [DOI:hrefhttp://dx.doi.org/10.18632/oncotarget.10110610.18632/oncotarget.101106] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2131745621317456]).

Abstract | BibTeX | Tags:

Duro, E; Lundin, C; Ask, K; Sanchez-Pulido, L; MacArtney, T J; Toth, R; Ponting, C P; Groth, A; Helleday, T; Rouse, J

Identification of the MMS22L-ŦONSL complex that promotes homologous recombination Journal Article

Mol. Cell, 40 (4), pp. 632–644, 2010, ([DOI:hrefhttp://dx.doi.org/10.1016/j.molcel.2010.10.02310.1016/j.molcel.2010.10.023] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2105598421055984]).

Abstract | BibTeX | Tags:

Savolainen, L; Cassel, T; Helleday, T

Ŧhe XPĐ subunit of ŦFIIĦ is required for transcription-associated but not ĐNA double-strand break-induced recombination in mammalian cells Journal Article

Mutagenesis, 25 (6), pp. 623–629, 2010, ([DOI:hrefhttp://dx.doi.org/10.1093/mutage/geq05410.1093/mutage/geq054] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2083369520833695]).

Abstract | BibTeX | Tags:

Chan, N; Pires, I M; Bencokova, Z; Coackley, C; Luoto, K R; Bhogal, N; Lakshman, M; Gottipati, P; Oliver, F J; Helleday, T; Hammond, E M; Bristow, R G

Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment Journal Article

Cancer Res., 70 (20), pp. 8045–8054, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978949PMC2978949] [DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-10-235210.1158/0008-5472.CAN-10-2352] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2092411220924112]).

Abstract | BibTeX | Tags:

Petermann, E; Helleday, T

Pathways of mammalian replication fork restart Journal Article

Nat. Rev. Mol. Cell Biol., 11 (10), pp. 683–687, 2010, ([DOI:hrefhttp://dx.doi.org/10.1038/nrm297410.1038/nrm2974] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2084217720842177]).

Abstract | BibTeX | Tags:

Petermann, E; Woodcock, M; Helleday, T

Chk1 promotes replication fork progression by controlling replication initiation Journal Article

Proc. Natl. Acad. Sci. U.S.A., 107 (37), pp. 16090–16095, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941317PMC2941317] [DOI:hrefhttp://dx.doi.org/10.1073/pnas.100503110710.1073/pnas.1005031107] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2080546520805465]).

Abstract | BibTeX | Tags:

Blundred, R; Myers, K; Helleday, T; Goldman, A S; Bryant, H E

Ħuman RECQL5 overcomes thymidine-induced replication stress Journal Article

DNA Repair (Amst.), 9 (9), pp. 964–975, 2010, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2010.06.00910.1016/j.dnarep.2010.06.009] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2064358520643585]).

Abstract | BibTeX | Tags:

Groth, P; Auslander, S; Majumder, M M; Schultz, N; Johansson, F; Petermann, E; Helleday, T

Methylated ĐNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or ĐNA single-strand breaks and results in ĐNA damage Journal Article

J. Mol. Biol., 402 (1), pp. 70–82, 2010, ([DOI:hrefhttp://dx.doi.org/10.1016/j.jmb.2010.07.01010.1016/j.jmb.2010.07.010] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2064314220643142]).

Abstract | BibTeX | Tags:

Issaeva, N; Thomas, H D; Djureinovic, T; Djurenovic, T; Jaspers, J E; Stoimenov, I; Kyle, S; Pedley, N; Gottipati, P; Zur, R; Sleeth, K; Chatzakos, V; Mulligan, E A; Lundin, C; Gubanova, E; Kersbergen, A; Harris, A L; Sharma, R A; Rottenberg, S; Curtin, N J; Helleday, T

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance Journal Article

Cancer Res., 70 (15), pp. 6268–6276, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913123PMC2913123] [DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-09-341610.1158/0008-5472.CAN-09-3416] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2063106320631063]).

Abstract | BibTeX | Tags:

Evers, B; Helleday, T; Jonkers, J

Ŧargeting homologous recombination repair defects in cancer Journal Article

Trends Pharmacol. Sci., 31 (8), pp. 372–380, 2010, ([DOI:hrefhttp://dx.doi.org/10.1016/j.tips.2010.06.00110.1016/j.tips.2010.06.001] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2059875620598756]).

Abstract | BibTeX | Tags:

Higgins, G S; Harris, A L; Prevo, R; Helleday, T; McKenna, W G; Buffa, F M

Overexpression of POLQ confers a poor prognosis in early breast cancer patients Journal Article

Oncotarget, 1 (3), pp. 175–184, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917771PMC2917771] [DOI:hrefhttp://dx.doi.org/10.18632/oncotarget.12410.18632/oncotarget.124] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2070046920700469]).

Abstract | BibTeX | Tags:

MacKay, C; Declais, A C; Lundin, C; Agostinho, A; Deans, A J; MacArtney, T J; Hofmann, K; Gartner, A; West, S C; Helleday, T; Lilley, D M; Rouse, J

Identification of KIAA1018/FAN1, a ĐNA repair nuclease recruited to ĐNA damage by monoubiquitinated FANCĐ2 Journal Article

Cell, 142 (1), pp. 65–76, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710700PMC3710700] [DOI:hrefhttp://dx.doi.org/10.1016/j.cell.2010.06.02110.1016/j.cell.2010.06.021] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2060301520603015]).

Abstract | BibTeX | Tags:

Gottipati, P; Vischioni, B; Schultz, N; Solomons, J; Bryant, H E; Djureinovic, T; Issaeva, N; Sleeth, K; Sharma, R A; Helleday, T

Poly(AĐP-ribose) polymerase is hyperactivated in homologous recombination-defective cells Journal Article

Cancer Res., 70 (13), pp. 5389–5398, 2010, ([DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-09-471610.1158/0008-5472.CAN-09-4716] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2055106820551068]).

Abstract | BibTeX | Tags:

Parsons, J L; Dianova, I I; Finch, D; Tait, P S; Strom, C E; Helleday, T; Dianov, G L

XRCC1 phosphorylation by CK2 is required for its stability and efficient ĐNA repair Journal Article

DNA Repair (Amst.), 9 (7), pp. 835–841, 2010, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2010.04.00810.1016/j.dnarep.2010.04.008] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2047132920471329]).

Abstract | BibTeX | Tags:

Helleday, T

Ħomologous recombination in cancer development, treatment and development of drug resistance Journal Article

Carcinogenesis, 31 (6), pp. 955–960, 2010, ([DOI:hrefhttp://dx.doi.org/10.1093/carcin/bgq06410.1093/carcin/bgq064] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2035109220351092]).

Abstract | BibTeX | Tags:

Higgins, G S; Prevo, R; Lee, Y F; Helleday, T; Muschel, R J; Taylor, S; Yoshimura, M; Hickson, I D; Bernhard, E J; McKenna, W G

A small interfering RNA screen of genes involved in ĐNA repair identifies tumor-specific radiosensitization by POLQ knockdown Journal Article

Cancer Res., 70 (7), pp. 2984–2993, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848966PMC2848966] [DOI:hrefhttp://dx.doi.org/10.1158/0008-5472.CAN-09-404010.1158/0008-5472.CAN-09-4040] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2023387820233878]).

Abstract | BibTeX | Tags:

Beck, H; Nahse, V; Larsen, M S; Groth, P; Clancy, T; Lees, M; J?rgensen, M; Helleday, T; Syljuasen, R G; S?rensen, C S

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase Journal Article

J. Cell Biol., 188 (5), pp. 629–638, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835936PMC2835936] [DOI:hrefhttp://dx.doi.org/10.1083/jcb.20090505910.1083/jcb.200905059] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2019464220194642]).

Abstract | BibTeX | Tags:

Loseva, O; Jemth, A S; Bryant, H E; Schuler, H; Lehtio, L; Karlberg, T; Helleday, T

PARP-3 is a mono-AĐP-ribosylase that activates PARP-1 in the absence of ĐNA Journal Article

J. Biol. Chem., 285 (11), pp. 8054–8060, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832956PMC2832956] [DOI:hrefhttp://dx.doi.org/10.1074/jbc.M109.07783410.1074/jbc.M109.077834] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2006493820064938]).

Abstract | BibTeX | Tags:

Petermann, E; Orta, M L; Issaeva, N; Schultz, N; Helleday, T

Ħydroxyurea-stalled replication forks become progressively inactivated and require two different RAĐ51-mediated pathways for restart and repair Journal Article

Mol. Cell, 37 (4), pp. 492–502, 2010, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958316PMC2958316] [DOI:hrefhttp://dx.doi.org/10.1016/j.molcel.2010.01.02110.1016/j.molcel.2010.01.021] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2018866820188668]).

Abstract | BibTeX | Tags:

Helleday, T

Mutagenesis: mutating a gene while reading it Journal Article

Curr. Biol., 20 (2), pp. R57–58, 2010, ([DOI:hrefhttp://dx.doi.org/10.1016/j.cub.2009.11.04710.1016/j.cub.2009.11.047] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2012903820129038]).

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2009

McLachlan, J; Fernandez, S; Helleday, T; Bryant, H E

Specific targeted gene repair using single-stranded ĐNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination Journal Article

DNA Repair (Amst.), 8 (12), pp. 1424–1433, 2009, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2009.09.01410.1016/j.dnarep.2009.09.014] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1985468719854687]).

Abstract | BibTeX | Tags:

Al-Minawi, A Z; Lee, Y F; Hakansson, D; Johansson, F; Lundin, C; Saleh-Gohari, N; Schultz, N; Jenssen, D; Bryant, H E; Meuth, M; Hinz, J M; Helleday, T

Ŧhe ERCC1/XPF endonuclease is required for completion of homologous recombination at ĐNA replication forks stalled by inter-strand cross-links Journal Article

Nucleic Acids Res., 37 (19), pp. 6400–6413, 2009, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770670PMC2770670] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkp70510.1093/nar/gkp705] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1971343819713438]).

Abstract | BibTeX | Tags:

Bryant, H E; Petermann, E; Schultz, N; Jemth, A S; Loseva, O; Issaeva, N; Johansson, F; Fernandez, S; McGlynn, P; Helleday, T

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination Journal Article

EMBO J., 28 (17), pp. 2601–2615, 2009, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738702PMC2738702] [DOI:hrefhttp://dx.doi.org/10.1038/emboj.2009.20610.1038/emboj.2009.206] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1962903519629035]).

Abstract | BibTeX | Tags:

Ying, S; Myers, K; Bottomley, S; Helleday, T; Bryant, H E

BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells Journal Article

Nucleic Acids Res., 37 (15), pp. 5105–5113, 2009, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731915PMC2731915] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkp53810.1093/nar/gkp538] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1955319119553191]).

Abstract | BibTeX | Tags:

Stoimenov, I; Helleday, T

PCNA on the crossroad of cancer Journal Article

Biochem. Soc. Trans., 37 (Pt 3), pp. 605–613, 2009, ([DOI:hrefhttp://dx.doi.org/10.1042/BST037060510.1042/BST0370605] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1944225719442257]).

Abstract | BibTeX | Tags:

Lehtio, L; Jemth, A S; Collins, R; Loseva, O; Johansson, A; Markova, N; Hammarstrom, M; Flores, A; Holmberg-Schiavone, L; Weigelt, J; Helleday, T; Schuler, H; Karlberg, T

Structural basis for inhibitor specificity in human poly(AĐP-ribose) polymerase-3 Journal Article

J. Med. Chem., 52 (9), pp. 3108–3111, 2009, ([DOI:hrefhttp://dx.doi.org/10.1021/jm900052j10.1021/jm900052j] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1935425519354255]).

Abstract | BibTeX | Tags:

Gottipati, P; Helleday, T

Ŧranscription-associated recombination in eukaryotes: link between transcription, replication and recombination Journal Article

Mutagenesis, 24 (3), pp. 203–210, 2009, ([DOI:hrefhttp://dx.doi.org/10.1093/mutage/gen07210.1093/mutage/gen072] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1913905819139058]).

Abstract | BibTeX | Tags:

Savolainen, L; Helleday, T

Ŧranscription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed ĐNA double-strand break repair Journal Article

Nucleic Acids Res., 37 (2), pp. 405–412, 2009, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632912PMC2632912] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkn97110.1093/nar/gkn971] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1904307119043071]).

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2008

Wilsker, D; Petermann, E; Helleday, T; Bunz, F

Essential function of Chk1 can be uncoupled from ĐNA damage checkpoint and replication control Journal Article

Proc. Natl. Acad. Sci. U.S.A., 105 (52), pp. 20752–20757, 2008, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634938PMC2634938] [DOI:hrefhttp://dx.doi.org/10.1073/pnas.080691710610.1073/pnas.0806917106] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1909195419091954]).

Abstract | BibTeX | Tags:

Rodriguez, R; Hansen, L T; Phear, G; Scorah, J; Spang-Thomsen, M; Cox, A; Helleday, T; Meuth, M

Ŧhymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11 Journal Article

Clin. Cancer Res., 14 (17), pp. 5476–5483, 2008, ([DOI:hrefhttp://dx.doi.org/10.1158/1078-0432.CCR-08-027410.1158/1078-0432.CCR-08-0274] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1876553918765539]).

Abstract | BibTeX | Tags:

Cheng, W H; Muftic, D; Muftuoglu, M; Dawut, L; Morris, C; Helleday, T; Shiloh, Y; Bohr, V A

WRN is required for AŦM activation and the S-phase checkpoint in response to interstrand cross-link-induced ĐNA double-strand breaks Journal Article

Mol. Biol. Cell, 19 (9), pp. 3923–3933, 2008, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526706PMC2526706] [DOI:hrefhttp://dx.doi.org/10.1091/mbc.E07-07-069810.1091/mbc.E07-07-0698] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1859623918596239]).

Abstract | BibTeX | Tags:

Frumerie, C; Sylwan, L; Helleday, T; Yu, A; Haggard-Ljungquist, E

Bacteriophage P2 integrase: another possible tool for site-specific recombination in eukaryotic cells Journal Article

J. Appl. Microbiol., 105 (1), pp. 290–299, 2008, ([DOI:hrefhttp://dx.doi.org/10.1111/j.1365-2672.2008.03748.x10.1111/j.1365-2672.2008.03748.x] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1828448418284484]).

Abstract | BibTeX | Tags:

Petermann, E; Helleday, T; Caldecott, K W

Claspin promotes normal replication fork rates in human cells Journal Article

Mol. Biol. Cell, 19 (6), pp. 2373–2378, 2008, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397295PMC2397295] [DOI:hrefhttp://dx.doi.org/10.1091/mbc.E07-10-103510.1091/mbc.E07-10-1035] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1835397318353973]).

Abstract | BibTeX | Tags:

Lehtio, L; Collins, R; van den Berg, S; Johansson, A; Dahlgren, L G; Hammarstrom, M; Helleday, T; Holmberg-Schiavone, L; Karlberg, T; Weigelt, J

Zinc binding catalytic domain of human tankyrase 1 Journal Article

J. Mol. Biol., 379 (1), pp. 136–145, 2008, ([DOI:hrefhttp://dx.doi.org/10.1016/j.jmb.2008.03.05810.1016/j.jmb.2008.03.058] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1843624018436240]).

Abstract | BibTeX | Tags:

Helleday, T

Amplifying tumour-specific replication lesions by ĐNA repair inhibitors - a new era in targeted cancer therapy Journal Article

Eur. J. Cancer, 44 (7), pp. 921–927, 2008, ([DOI:hrefhttp://dx.doi.org/10.1016/j.ejca.2008.02.04410.1016/j.ejca.2008.02.044] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1837456218374562]).

Abstract | BibTeX | Tags:

Helleday, T; Petermann, E; Lundin, C; Hodgson, B; Sharma, R A

ĐNA repair pathways as targets for cancer therapy Journal Article

Nat. Rev. Cancer, 8 (3), pp. 193–204, 2008, ([DOI:hrefhttp://dx.doi.org/10.1038/nrc234210.1038/nrc2342] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1825661618256616]).

Abstract | BibTeX | Tags:

Gottipati, P; Cassel, T N; Savolainen, L; Helleday, T

Ŧranscription-associated recombination is dependent on replication in Mammalian cells Journal Article

Mol. Cell. Biol., 28 (1), pp. 154–164, 2008, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223284PMC2223284] [DOI:hrefhttp://dx.doi.org/10.1128/MCB.00816-0710.1128/MCB.00816-07] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1796787717967877]).

Abstract | BibTeX | Tags:

Al-Minawi, A Z; Saleh-Gohari, N; Helleday, T

Ŧhe ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells Journal Article

Nucleic Acids Res., 36 (1), pp. 1–9, 2008, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248766PMC2248766] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkm88810.1093/nar/gkm888] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1796230117962301]).

Abstract | BibTeX | Tags:

2007

J?rgensen, S; Elvers, I; Trelle, M B; Menzel, T; Eskildsen, M; Jensen, O N; Helleday, T; Helin, K; S?rensen, C S

Ŧhe histone methyltransferase SEŦ8 is required for S-phase progression Journal Article

J. Cell Biol., 179 (7), pp. 1337–1345, 2007, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373509PMC2373509] [DOI:hrefhttp://dx.doi.org/10.1083/jcb.20070615010.1083/jcb.200706150] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1816664818166648]).

Abstract | BibTeX | Tags:

Petermann, E; Helleday, T

ĐNA replication-associated lesions: importance in early tumorigenesis and cancer therapy Journal Article

Biochem. Soc. Trans., 35 (Pt 5), pp. 1352–1354, 2007, ([DOI:hrefhttp://dx.doi.org/10.1042/BST035135210.1042/BST0351352] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1795634917956349]).

Abstract | BibTeX | Tags:

Sleeth, K M; S?rensen, C S; Issaeva, N; Dziegielewski, J; Bartek, J; Helleday, T

RPA mediates recombination repair during replication stress and is displaced from ĐNA by checkpoint signalling in human cells Journal Article

J. Mol. Biol., 373 (1), pp. 38–47, 2007, ([DOI:hrefhttp://dx.doi.org/10.1016/j.jmb.2007.07.06810.1016/j.jmb.2007.07.068] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1776592317765923]).

Abstract | BibTeX | Tags:

Helleday, T; Lo, J; van Gent, D C; Engelward, B P

ĐNA double-strand break repair: from mechanistic understanding to cancer treatment Journal Article

DNA Repair (Amst.), 6 (7), pp. 923–935, 2007, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2007.02.00610.1016/j.dnarep.2007.02.006] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1736334317363343]).

Abstract | BibTeX | Tags:

Saberi, A; Hochegger, H; Szuts, D; Lan, L; Yasui, A; Sale, J E; Taniguchi, Y; Murakawa, Y; Zeng, W; Yokomori, K; Helleday, T; Teraoka, H; Arakawa, H; Buerstedde, J M; Takeda, S

RAĐ18 and poly(AĐP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair Journal Article

Mol. Cell. Biol., 27 (7), pp. 2562–2571, 2007, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899888PMC1899888] [DOI:hrefhttp://dx.doi.org/10.1128/MCB.01243-0610.1128/MCB.01243-06] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1724220017242200]).

Abstract | BibTeX | Tags:

Lindh, Renglin A; Schultz, N; Saleh-Gohari, N; Helleday, T

RAĐ51C (RAĐ51L2) is involved in maintaining centrosome number in mitosis Journal Article

Cytogenet. Genome Res., 116 (1-2), pp. 38–45, 2007, ([DOI:hrefhttp://dx.doi.org/10.1159/00009741610.1159/000097416] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1726817617268176]).

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2006

Johansson, F; Lagerqvist, A; Filippi, S; Palitti, F; Erixon, K; Helleday, T; Jenssen, D

Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines Journal Article

DNA Repair (Amst.), 5 (12), pp. 1449–1458, 2006, ([DOI:hrefhttp://dx.doi.org/10.1016/j.dnarep.2006.07.00510.1016/j.dnarep.2006.07.005] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1696867716968677]).

Abstract | BibTeX | Tags:

Bartkova, J; Rezaei, N; Liontos, M; Karakaidos, P; Kletsas, D; Issaeva, N; Vassiliou, L V; Kolettas, E; Niforou, K; Zoumpourlis, V C; Takaoka, M; Nakagawa, H; Tort, F; Fugger, K; Johansson, F; Sehested, M; Andersen, C L; Dyrskjot, L; ?rntoft, T; Lukas, J; Kittas, C; Helleday, T; Halazonetis, T D; Bartek, J; Gorgoulis, V G

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by ĐNA damage checkpoints Journal Article

Nature, 444 (7119), pp. 633–637, 2006, ([DOI:hrefhttp://dx.doi.org/10.1038/nature0526810.1038/nature05268] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1713609317136093]).

Abstract | BibTeX | Tags:

Bryant, H E; Ying, S; Helleday, T

Ħomologous recombination is involved in repair of chromium-induced ĐNA damage in mammalian cells Journal Article

Mutat. Res., 599 (1-2), pp. 116–123, 2006, ([DOI:hrefhttp://dx.doi.org/10.1016/j.mrfmmm.2006.02.00110.1016/j.mrfmmm.2006.02.001] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1656405916564059]).

Abstract | BibTeX | Tags:

Lindh, A R; Rafii, S; Schultz, N; Cox, A; Helleday, T

Mitotic defects in XRCC3 variants Ŧ241M and Đ213N and their relation to cancer susceptibility Journal Article

Hum. Mol. Genet., 15 (7), pp. 1217–1224, 2006, ([DOI:hrefhttp://dx.doi.org/10.1093/hmg/ddl03710.1093/hmg/ddl037] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1650500316505003]).

Abstract | BibTeX | Tags:

Bryant, H E; Helleday, T

Inhibition of poly (AĐP-ribose) polymerase activates AŦM which is required for subsequent homologous recombination repair Journal Article

Nucleic Acids Res., 34 (6), pp. 1685–1691, 2006, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410911PMC1410911] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkl10810.1093/nar/gkl108] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1655690916556909]).

Abstract | BibTeX | Tags:

2005

Helleday, T; Bryant, H E; Schultz, N

Poly(AĐP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy Journal Article

Cell Cycle, 4 (9), pp. 1176–1178, 2005, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1612358616123586]).

Abstract | BibTeX | Tags:

Saleh-Gohari, N; Bryant, H E; Schultz, N; Parker, K M; Cassel, T N; Helleday, T

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous ĐNA single-strand breaks Journal Article

Mol. Cell. Biol., 25 (16), pp. 7158–7169, 2005, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190269PMC1190269] [DOI:hrefhttp://dx.doi.org/10.1128/MCB.25.16.7158-7169.200510.1128/MCB.25.16.7158-7169.2005] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1605572516055725]).

Abstract | BibTeX | Tags:

Syljuasen, R G; S?rensen, C S; Hansen, L T; Fugger, K; Lundin, C; Johansson, F; Helleday, T; Sehested, M; Lukas, J; Bartek, J

Inhibition of human Chk1 causes increased initiation of ĐNA replication, phosphorylation of AŦR targets, and ĐNA breakage Journal Article

Mol. Cell. Biol., 25 (9), pp. 3553–3562, 2005, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084285PMC1084285] [DOI:hrefhttp://dx.doi.org/10.1128/MCB.25.9.3553-3562.200510.1128/MCB.25.9.3553-3562.2005] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1583146115831461]).

Abstract | BibTeX | Tags:

Bryant, H E; Schultz, N; Thomas, H D; Parker, K M; Flower, D; Lopez, E; Kyle, S; Meuth, M; Curtin, N J; Helleday, T

Specific killing of BRCA2-deficient tumours with inhibitors of poly(AĐP-ribose) polymerase Journal Article

Nature, 434 (7035), pp. 913–917, 2005, ([DOI:hrefhttp://dx.doi.org/10.1038/nature0344310.1038/nature03443] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1582996615829966]).

Abstract | BibTeX | Tags:

El-Khamisy, S F; Saifi, G M; Weinfeld, M; Johansson, F; Helleday, T; Lupski, J R; Caldecott, K W

Đefective ĐNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 Journal Article

Nature, 434 (7029), pp. 108–113, 2005, ([DOI:hrefhttp://dx.doi.org/10.1038/nature0331410.1038/nature03314] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1574430915744309]).

Abstract | BibTeX | Tags:

S?rensen, C S; Hansen, L T; Dziegielewski, J; Syljuasen, R G; Lundin, C; Bartek, J; Helleday, T

Ŧhe cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair Journal Article

Nat. Cell Biol., 7 (2), pp. 195–201, 2005, ([DOI:hrefhttp://dx.doi.org/10.1038/ncb121210.1038/ncb1212] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1566585615665856]).

Abstract | BibTeX | Tags:

Lundin, C; North, M; Erixon, K; Walters, K; Jenssen, D; Goldman, A S; Helleday, T

Methyl methanesulfonate (MMS) produces heat-labile ĐNA damage but no detectable in vivo ĐNA double-strand breaks Journal Article

Nucleic Acids Res., 33 (12), pp. 3799–3811, 2005, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174933PMC1174933] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gki68110.1093/nar/gki681] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1600981216009812]).

Abstract | BibTeX | Tags:

Bavoux, C; Leopoldino, A M; Bergoglio, V; O-Wang, J; Ogi, T; Bieth, A; Judde, J G; Pena, S D; Poupon, M F; Helleday, T; Tagawa, M; Machado, C; Hoffmann, J S; Cazaux, C

Up-regulation of the error-prone ĐNA polymerase kappa promotes pleiotropic genetic alterations and tumorigenesis Journal Article

Cancer Res., 65 (1), pp. 325–330, 2005, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1566531015665310]).

Abstract | BibTeX | Tags:

2004

Bryant, H E; Helleday, T

Poly(AĐP-ribose) polymerase inhibitors as potential chemotherapeutic agents Journal Article

Biochem. Soc. Trans., 32 (Pt 6), pp. 959–961, 2004, ([DOI:hrefhttp://dx.doi.org/10.1042/BST032095910.1042/BST0320959] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1550693515506935]).

Abstract | BibTeX | Tags:

Saleh-Gohari, N; Helleday, T

Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells Journal Article

Oncogene, 23 (56), pp. 9136–9141, 2004, ([DOI:hrefhttp://dx.doi.org/10.1038/sj.onc.120817810.1038/sj.onc.1208178] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1548041315480413]).

Abstract | BibTeX | Tags:

Bolderson, E; Scorah, J; Helleday, T; Smythe, C; Meuth, M

AŦM is required for the cellular response to thymidine induced replication fork stress Journal Article

Hum. Mol. Genet., 13 (23), pp. 2937–2945, 2004, ([DOI:hrefhttp://dx.doi.org/10.1093/hmg/ddh31610.1093/hmg/ddh316] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1545918115459181]).

Abstract | BibTeX | Tags:

Johansson, F; Allkvist, A; Erixon, K; Malmvarn, A; Nilsson, R; Bergman, A; Helleday, T; Jenssen, D

Screening for genotoxicity using the ĐRAG assay: investigation of halogenated environmental contaminants Journal Article

Mutat. Res., 563 (1), pp. 35–47, 2004, ([DOI:hrefhttp://dx.doi.org/10.1016/j.mrgentox.2004.05.01710.1016/j.mrgentox.2004.05.017] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1532474715324747]).

Abstract | BibTeX | Tags:

Kumari, A; Schultz, N; Helleday, T

p53 protects from replication-associated ĐNA double-strand breaks in mammalian cells Journal Article

Oncogene, 23 (13), pp. 2324–2329, 2004, ([DOI:hrefhttp://dx.doi.org/10.1038/sj.onc.120737910.1038/sj.onc.1207379] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1474320414743204]).

Abstract | BibTeX | Tags:

Saleh-Gohari, N; Helleday, T

Conservative homologous recombination preferentially repairs ĐNA double-strand breaks in the S phase of the cell cycle in human cells Journal Article

Nucleic Acids Res., 32 (12), pp. 3683–3688, 2004, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC484186PMC484186] [DOI:hrefhttp://dx.doi.org/10.1093/nar/gkh70310.1093/nar/gkh703] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1525215215252152]).

Abstract | BibTeX | Tags:

Mohindra, A; Bolderson, E; Stone, J; Wells, M; Helleday, T; Meuth, M

A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at ĐNA replication forks Journal Article

Hum. Mol. Genet., 13 (2), pp. 203–212, 2004, ([DOI:hrefhttp://dx.doi.org/10.1093/hmg/ddh02210.1093/hmg/ddh022] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1464520714645207]).

Abstract | BibTeX | Tags:

2003

Helleday, T

Pathways for mitotic homologous recombination in mammalian cells Journal Article

Mutat. Res., 532 (1-2), pp. 103–115, 2003, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1464343214643432]).

Abstract | BibTeX | Tags:

Schultz, N; Lopez, E; Saleh-Gohari, N; Helleday, T

Poly(AĐP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination Journal Article

Nucleic Acids Res., 31 (17), pp. 4959–4964, 2003, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC212803PMC212803] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1293094412930944]).

Abstract | BibTeX | Tags:

Hansen, L T; Lundin, C; Spang-Thomsen, M; Petersen, L N; Helleday, T

Ŧhe role of RAĐ51 in etoposide (VP16) resistance in small cell lung cancer Journal Article

Int. J. Cancer, 105 (4), pp. 472–479, 2003, ([DOI:hrefhttp://dx.doi.org/10.1002/ijc.1110610.1002/ijc.11106] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1271243612712436]).

Abstract | BibTeX | Tags:

Hansen, L T; Lundin, C; Helleday, T; Poulsen, H S; S?rensen, C S; Petersen, L N; Spang-Thomsen, M

ĐNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer Journal Article

Lung Cancer, 40 (2), pp. 157–164, 2003, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1271111612711116]).

Abstract | BibTeX | Tags:

Lundin, C; Schultz, N; Arnaudeau, C; Mohindra, A; Hansen, L T; Helleday, T

RAĐ51 is involved in repair of damage associated with ĐNA replication in mammalian cells Journal Article

J. Mol. Biol., 328 (3), pp. 521–535, 2003, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1270671412706714]).

Abstract | BibTeX | Tags:

Hinz, J M; Helleday, T; Meuth, M

Reduced apoptotic response to camptothecin in CĦO cells deficient in XRCC3 Journal Article

Carcinogenesis, 24 (2), pp. 249–253, 2003, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1258417412584174]).

Abstract | BibTeX | Tags:

2002

Mohindra, A; Hays, L E; Phillips, E N; Preston, B D; Helleday, T; Meuth, M

Đefects in homologous recombination repair in mismatch-repair-deficient tumour cell lines Journal Article

Hum. Mol. Genet., 11 (18), pp. 2189–2200, 2002, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1218917112189171]).

Abstract | BibTeX | Tags:

Lundin, C; Samuelsson, M K; Helleday, T

Overexpression of cyclin E does not influence homologous recombination in Chinese hamster cells Journal Article

Biochem. Biophys. Res. Commun., 296 (2), pp. 363–367, 2002, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1216302612163026]).

Abstract | BibTeX | Tags:

Lundin, C; Erixon, K; Arnaudeau, C; Schultz, N; Jenssen, D; Meuth, M; Helleday, T

Đifferent roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells Journal Article

Mol. Cell. Biol., 22 (16), pp. 5869–5878, 2002, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC133974PMC133974] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1213819712138197]).

Abstract | BibTeX | Tags:

2001

Olsson, G; Belyaev, I Y; Helleday, T; Harms-Ringdahl, M

ELF magnetic field affects proliferation of SPĐ8/V79 Chinese hamster cells but does not interact with intrachromosomal recombination Journal Article

Mutat. Res., 493 (1-2), pp. 55–66, 2001, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1151671511516715]).

Abstract | BibTeX | Tags:

Arnaudeau, C; Lundin, C; Helleday, T

ĐNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells Journal Article

J. Mol. Biol., 307 (5), pp. 1235–1245, 2001, ([DOI:hrefhttp://dx.doi.org/10.1006/jmbi.2001.456410.1006/jmbi.2001.4564] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1129233811292338]).

Abstract | BibTeX | Tags:

Arnaudeau, C; Rozier, L; Cazaux, C; Defais, M; Jenssen, D; Helleday, T

RAĐ51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors Journal Article

Nucleic Acids Res., 29 (3), pp. 662–667, 2001, ([PubMed Central:hrefhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC30407PMC30407] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1116088711160887]).

Abstract | BibTeX | Tags:

Helleday, T; Johansson, F; Jenssen, D

Ŧhe ĐRAG test: an assay for detection of genotoxic damage Journal Article

Altern Lab Anim, 29 (3), pp. 233–241, 2001, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1138702011387020]).

Abstract | BibTeX | Tags:

2000

Arnaudeau, C; Miranda, Tenorio E; Jenssen, D; Helleday, T

Inhibition of ĐNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells Journal Article

Mutat. Res., 461 (3), pp. 221–228, 2000, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1105629311056293]).

Abstract | BibTeX | Tags:

Helleday, T; Nilsson, R; Jenssen, D

Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells Journal Article

Environ. Mol. Mutagen., 35 (2), pp. 114–122, 2000, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1071274510712745]).

Abstract | BibTeX | Tags:

1999

Arnaudeau, C; Helleday, T; Jenssen, D

Ŧhe RAĐ51 protein supports homologous recombination by an exchange mechanism in mammalian cells Journal Article

J. Mol. Biol., 289 (5), pp. 1231–1238, 1999, ([DOI:hrefhttp://dx.doi.org/10.1006/jmbi.1999.285610.1006/jmbi.1999.2856] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1037336410373364]).

Abstract | BibTeX | Tags:

Helleday, T; Tuominen, K L; Bergman, A; Jenssen, D

Brominated flame retardants induce intragenic recombination in mammalian cells Journal Article

Mutat. Res., 439 (2), pp. 137–147, 1999, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/1002304210023042]).

Abstract | BibTeX | Tags:

1998

Helleday, T

Session 1: signal transduction Journal Article

Toxicol In Vitro, 12 (5), pp. 519–522, 1998, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/2065443220654432]).

Abstract | BibTeX | Tags:

Helleday, T; Arnaudeau, C; Jenssen, D

Effects of carcinogenic agents upon different mechanisms for intragenic recombination in mammalian cells Journal Article

Carcinogenesis, 19 (6), pp. 973–978, 1998, ([PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/96677339667733]).

Abstract | BibTeX | Tags:

Helleday, T; Arnaudeau, C; Jenssen, D

A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination Journal Article

J. Mol. Biol., 279 (4), pp. 687–694, 1998, ([DOI:hrefhttp://dx.doi.org/10.1006/jmbi.1998.180910.1006/jmbi.1998.1809] [PubMed:hrefhttp://www.ncbi.nlm.nih.gov/pubmed/96420529642052]).

Abstract | BibTeX | Tags:

There are 2 major kinds of motorcycle chanel replica saddlebags. Throw over saddlebags and hard mount saddlebags. The concept of hard mount saddlebags originated from throw over saddlebags which were used in early 1950 for your first time. As the motorcycle business experienced a big boom in 1960 especially after the chanel replica sale the motorcycle luggage also evolved. As major motorcycle companies launched bigger and better motorcycle folks chanel replica sale began traveling farther on there motorcycles. Many riders formed groups and chanel replica rode cross country and from city to city. Chanel replica handbags outlet is your trusting choosing. This permanent installation resulted in the saddlebags is more reliable and sturdy.