Publications

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2017

Nikolas Herold Sean G Rudd, Linda Ljungblad Kumar Sanjiv Ida Hed Myrberg Cynthia Paulin Yaser Heshmati Anna Hagenkort Juliane Kutzner Brent Page José Calderón-Montaño Olga Loseva Ann-Sofie Jemth Lorenzo Bulli Hanna Axelsson Bianca Tesi Nicholas Valerie Andreas Höglund Julia Bladh Elisée Wiita Mikael Sundin Michael Uhlin Georgios Rassidakis Mats Heyman Katja Pokrovskaja Tamm Ulrika Warpman-Berglund Julian Walfridsson Sören Lehmann Dan Grandér Thomas Lundbäck Per Kogner Jan-Inge Henter Thomas Helleday & Torsten Schaller B J D G M C K

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Journal Article

Nat Med, (23), pp. 256-263, 2017.

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Sanjiv K Hagenkort A, Calderón-Montaño JM Koolmeister Reaper PM Mortusewicz Jacques SA Kuiper RV Schultz Scobie Charlton PA Pollard JR Berglund UW Altun Helleday T O N M M T

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Journal Article

Cell Rep, 17 (12), pp. 3407-3416, 2017.

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Sokolova M Turunen M, Mortusewicz Kivioja Herr Vähärautio Björklund Taipale Helleday Taipale O T P A M M T J

Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Journal Article

Cell Cykle, 16 (2), pp. 189-199, 2017.

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Llona-Minguez S Höglund A, Wiita Almlöf Mateus Calderón-Montaño JM Cazares-Körner Homan Loseva Baranczewski Jemth AS Häggblad Martens Lundgren Artursson Lundbäck Jenmalm Jensen Warpman Berglund Scobie Helleday E I A C E O P M U B P T A U M T

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. Journal Article

J Med Chem, 2017.

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Gustafsson R Jemth AS, Gustafsson NM Färnegårdh Loseva Wiita Bonagas Dahllund Llona-Minguez Häggblad Henriksson Andersson Homan Helleday Stenmark K O E N L S M M Y E T P

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Journal Article

Cancer res, 77 (4), pp. 937-948, 2017.

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Thålin C Daleskog M, Göransson SP Schatzberg Lasselin Laska AC Kallner Helleday Wallén Demers D J A T H M

Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma. Journal Article

Immunol Res. , 2017.

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Ogris C Guala D, Helleday Sonnhammer EL. T

A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation. Journal Article

Nucleic Acids Res., 2017.

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2016

Tanikawa M1 Sanjiv K1, Helleday Herr Mortusewicz T1 P1 O1

The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing Journal Article

Oncogenesis, 5 (12), pp. e280, 2016.

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Eshtad S Mavajian Z, Rudd SG Visnes Boström Altun Helleday T J M T

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Journal Article

Oncogenesis, 2016.

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Valerie NC Hagenkort A, Page BD Masuyer Rehling Carter Bevc Herr Homan Sheppard NG Stenmark Jemth AS Helleday G D M L P E P T

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. Journal Article

pp. 5501-11, 2016.

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Ogris C Helleday T, Sonnhammer EL.

PathwAX: a web server for network crosstalk based pathway annotation. Journal Article

Nucleic Acids Res., 2016.

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Jackson SP, Helleday T

DNA REPAIR. Drugging DNA repair. Journal Article

Science, 352 (6290), pp. 1178-9, 2016.

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Rudd SG Valerie NC, Helleday T

Pathways controlling dNTP pools to maintain genome stability. Journal Article

DNA repair, (44), pp. 193-204, 2016.

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Llona-Minguez S Höglund A, Jacques SA Johansson Calderón-Montaño JM Claesson Loseva Valerie NC Lundbäck Piedrafita Maga Crespan Meijer Burgos Morón Baranczewski Hagbjörk AL Svensson Wiita Almlöf Visnes Jeppsson Sigmundsson Jensen AJ Artursson Jemth AS Stenmark Warpman Berglund Scobie L M O T J G E L E P R E I T F K P P U M; T, Helleday

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Journal Article

J Med Chem, 59 (3), pp. 1140-8, 2016.

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2015

Puigvert JC, Sanjiv K; T., Helleday

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies. Journal Article

FEBS J, 282 (2), pp. 232-45, 2015.

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