Publications

 

Show all

2018

Jemth, Ann-Sofie; Gustafsson, Robert; Bräutigam, Lars; Henriksson, Linda; Vallin, Karl S A; Sarno, Antonio; Almlöf, Ingrid; Homan, Evert; Rasti, Azita; Berglund, Ulrika Warpman; Stenmark, Pål; Helleday, Thomas

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP Journal Article

Nucleic Acid Research, 2018.

Abstract | Links | BibTeX | Tags: article

Gustafsson, Nina M S; Färnegårdh, Katarina; Bonagas, Nadilly; Ninou, Anna Huguet; Groth, Petra; Wiita, Elisee; Jönsson, Mattias; Hallberg, Kenth; Lehto, Jemina; Pennisi, Rosa; Martinsson, Jessica; Norström, Carina; Hollers, Jessica; Schultz, Johan; Andersson, Martin; Markova, Natalia; Marttila, Petra; Kim, Baek; Norin, Martin; Olin, Thomas; Helleday, Thomas

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination Journal Article

Nature Communications, 9 (3872), 2018.

Abstract | Links | BibTeX | Tags: article

Visnes, Torkild; Grube, Maurice; Hanna, Bishoy Magdy Fekry; Benitez-Buelga, Carlos; Cázares-Körner, Armando; Helleday, Thomas

Targeting BER enzymes in cancer therapy Journal Article

DNA Repair, 2018.

Abstract | Links | BibTeX | Tags: article

Einarsdottir, Berglind O; Karlsson, Joakim; Söderberg, Elin M V; Lindberg, Mattias F; Funck-Brentano, Elisa; Jespersen, Henrik; Brynjolfsson, Siggeir F; Bagge, Roger Olofsson; Carstam, Louise; Scobie, Martin; Koolmeister, Tobias; Wallner, Olov; Stierner, Ulrika; Berglund, Ulrika Warpman; Ny, Lars; Nilsson, Lisa M; Larsson, Erik; Helleday, Thomas; Nilsson, Jonas A

A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma Journal Article

Cell Death & Disease, 2018.

Abstract | Links | BibTeX | Tags: article

Berglund, Emelie; Maaskola, Jonas; Schultz, Niklas; Friedrich, Stefanie; Marklund, Maja; Bergenstråhle, Joseph; Tarish, Firas; Tanoglidi, Anna; Vickovic, Sanja; Larsson, Ludvig; Salmen, Fredrik; Ogris, Christoph; Wallenborg, Karolina; Lagergren, Jens; Ståhl, Patrik; Sonnhammer, Erik; Helleday, Thomas; Lundeberg, Joakim

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity Journal Article

Nature Communications, 9 , 2018.

Abstract | Links | BibTeX | Tags: article

Pilar Mur Ann‐Sofie Jemth, Luka Bevc Nuno Amaral Matilde Navarro Rafael Valdés‐Mas Tirso Pons Gemma Aiza Miguel Urioste Alfonso Valencia Conxi Lázaro Victor Moreno Xose Puente Stenmark Ulrika Warpman‐Berglund Gabriel Capellá Thomas Helleday Laura Valle S Pål

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis Journal Article

Human Mutation, 2018.

Abstract | Links | BibTeX | Tags: article

Riley, Andrew M; Unterlass, Judith E; Konieczny, Vera; Taylor, Colin W; Helleday, Thomas; Potter, Barry V L

A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate Journal Article

Med. Chem. Comm., 9 , pp. 1105-1113, 2018, (https://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00149A#!divAbstract).

Abstract | Links | BibTeX | Tags: article

Linda Pudelko Steven Edwards, Mirela Balan Daniel Nyqvist Jonathan Al-Saadi Johannes Dittmer Ingrid Almlöf Thomas Helleday Lars Bräutigam

An orthotopic glioblastoma animal model suitable for high-throughput screenings Journal Article

Neuro-Oncology, 2018.

Abstract | Links | BibTeX | Tags: article

Megan Carter Ann-Sofie Jemth, Jordi Carreras-Puigvert Patrick Herr Markel Martínez Carranza Karl Vallin Adam Throup Thomas Helleday Stenmark S A Pål

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold Journal Article

Cell Structure, 26 , pp. 295-303, 2018.

Abstract | BibTeX | Tags: article

Page Brent D. G.; Valerie, Nicholas Wright Roni Wallner Olov; Isaksson Rebecka; Carter Megan; Rudd Sean Loseva Olga; Jemth Ann-Sofie; Almloef Ingrid; Font-Mateu Jofre; Llona-Minguez Sabin; Baranczewski Pawel; Jeppsson Fredrik; Homan Evert; Almqvist Helena; Axelsson Hanna; Regmi Shruti; Gustavsson Anna-Lena; Lundbaeck Thomas; Scobie Martin; Stroemberg Kia; Stenmark Paal; Beato Miguel; Helleday Thomas. C K ; H G ; G ;

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells Journal Article

Nature Communications, 9 , pp. 1-14, 2018.

Abstract | Links | BibTeX | Tags: article

2017

Mohit Narwal Ann-Sofie Jemth, Robert Gustafsson Ingrid Almlöf Ulrika Warpman Berglund Thomas Helleday Stenmark Pål

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity Journal Article

Biochemistry, 57 (5), pp. 593-603, 2017.

Abstract | Links | BibTeX | Tags: article

Jordi Carreras-Puigvert Marinka Zitnik, Ann-Sofie Jemth Megan Carter Judith Unterlass Björn Hallström Olga Loseva Zhir Karem José Manuel Calderón-Montaño Cecilia Lindskog Per-Henrik Edqvist Damian Matuszewski Hammou Ait Blal Ronnie Berntsson Maria Häggblad Ulf Martens Matthew Studham Bo Lundgren Carolina Wählby Erik Sonnhammer Emma Lundberg Stenmark Blaz Zupan Thomas Helleday E J P A L L Pål

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family Journal Article

Nature Communications, 8 , pp. 1541, 2017.

Abstract | Links | BibTeX | Tags: article

Axel Rudling Robert Gustafsson, Ingrid Almlöf Evert Homan Martin Scobie Ulrika Warpman Berglund Thomas Helleday Pål Stenmark Jens Carlsson

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space Journal Article

Journal of Medicinal Chemistry, 60 , pp. 8160-8169, 2017.

Abstract | Links | BibTeX | Tags: article

Linda Pudelko Pegah Rouhi, Kumar Sanjiv Helge Gad Christina Kalderén Andreas Höglund Massimo Squatrito Alberto Schuhmacher Steven Edwards Daniel Hägerstrand Ulrika Warpman Berglund Thomas Helleday Lars Bräutigam J

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 Journal Article

Oncotarget, 8 , pp. 84671-84684, 2017.

Abstract | Links | BibTeX | Tags: article

Sabin Llona-Minguez Artin Ghassemian, Pawel Baranczewski Matthieu Desroses Tobias Koolmeister Per Artursson Martin Scobie Thomas Helleday

Structure–metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines Journal Article

Med. Chem. Comm., 8 , pp. 1553-1560, 2017.

Abstract | Links | BibTeX | Tags: article

Iryna Kolosenko Yasmin Yu, Sander Busker Matheus Dyczynski Jianping Liu Martin Haraldsson Caroline Palm Apergi Thomas Helleday Katja Pokrovskaja Tamm Brent Page Dan Grander D G

Identification of novel small molecules that inhibit STAT3-dependent transcription and function Journal Article

Plos One, 2017.

Abstract | Links | BibTeX | Tags: article

Sabin Llona-Minguez Andreas Höglund, Artin Ghassemian Matthieu Desroses Jose Manuel Calderon-Montano Estefania Burgos Moron Nicholas Valerie Elisee Wiita Ingrid Almlöf Tobias Koolmeister Andre Mateus Cindy Cazares-Körner Kumar Sanjiv Evert Homan Olga Loseva Pawel Baranczewski Masoud Darabi Amir Mehdizadeh Shabnam Fayezi Ann-Sofie Jemth Ulrika Warpman Berglund Kristmundur Sigmundsson Thomas Lundbäck Annika Jenmalm Jensen Per Artursson Martin Scobie Thomas Helleday C K

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors Journal Article

Journal of Medicinal Chemistry, 60 , pp. 4279-4292, 2017.

Abstract | Links | BibTeX | Tags: article

Nikolas Herold Sean G. Rudd, Kumar Sanjiv Juliane Kutzner Julia Bladh Cynthia Paulin Thomas Helleday Jan-Inge Henter Torsten Schaller B J

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites Journal Article

Cell Cycle, 16 (11), pp. 1029-1038, 2017.

Abstract | Links | BibTeX | Tags: article

Nikolas Herold Sean G. Rudd, Kumar Sanjiv Juliane Kutzner Ida Hed Myrberga Cynthia Paulin Thale Kristin Olsen Thomas Helleday Jan-Inge Henter TorstenSchaller B J

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1 Journal Article

Experimental Hematology, 52 , pp. 32-39, 2017.

Abstract | Links | BibTeX | Tags: article

de la Gregory I Vladimer Berend Snijder, Nikolaus Krall Johannes Bigenzahn Kilian Huber Charles-Hugues Lardeau Kumar Sanjiv Anna Ringler Ulrika Warpman Berglund Monika Sabler Oscar Lopez Fuente Paul Knöbl Stefan Kubicek Thomas Helleday Ulrich Jäger Giulio Superti-Furga W V M

Global survey of the immunomodulatory potential of common drugs Journal Article

Nature Chemical Biology, 13 , pp. 681-690, 2017.

Abstract | Links | BibTeX | Tags: article

Anna Hagenkort Cynthia B.J. Paulin, Matthieu Desroses Antonio Sarno Elisée Wiita Oliver Mortusewicz Tobias Koolmeister Olga Loseva Ann-Sofie Jemth Ingrid Almlöf Evert Homan Thomas Lundbäck Anna-Lena Gustavsson Martin Scobie Thomas Helleday

dUTPase inhibition augments replication defects of 5-Fluorouracil Journal Article

Oncotarget, 8 , pp. 23713-23726, 2017.

Abstract | Links | BibTeX | Tags: article

Nikolas Herold Sean G Rudd, Linda Ljungblad Kumar Sanjiv Ida Hed Myrberg Cynthia Paulin Yaser Heshmati Anna Hagenkort Juliane Kutzner Brent Page José Calderón-Montaño Olga Loseva Ann-Sofie Jemth Lorenzo Bulli Hanna Axelsson Bianca Tesi Nicholas Valerie Andreas Höglund Julia Bladh Elisée Wiita Mikael Sundin Michael Uhlin Georgios Rassidakis Mats Heyman Katja Pokrovskaja Tamm Ulrika Warpman-Berglund Julian Walfridsson Sören Lehmann Dan Grandér Thomas Lundbäck Per Kogner Jan-Inge Henter Thomas Helleday & Torsten Schaller B J D G M C K

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Journal Article

Nat Med, (23), pp. 256-263, 2017.

Abstract | Links | BibTeX | Tags: article

Sanjiv K Hagenkort A, Calderón-Montaño JM Koolmeister Reaper PM Mortusewicz Jacques SA Kuiper RV Schultz Scobie Charlton PA Pollard JR Berglund UW Altun Helleday T O N M M T

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Journal Article

Cell Rep, 17 (12), pp. 3407-3416, 2017.

Links | BibTeX | Tags: article

Sokolova M Turunen M, Mortusewicz Kivioja Herr Vähärautio Björklund Taipale Helleday Taipale O T P A M M T J

Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Journal Article

Cell Cykle, 16 (2), pp. 189-199, 2017.

Links | BibTeX | Tags: article

Llona-Minguez S Höglund A, Wiita Almlöf Mateus Calderón-Montaño JM Cazares-Körner Homan Loseva Baranczewski Jemth AS Häggblad Martens Lundgren Artursson Lundbäck Jenmalm Jensen Warpman Berglund Scobie Helleday E I A C E O P M U B P T A U M T

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. Journal Article

J Med Chem, 2017.

Links | BibTeX | Tags: article

Gustafsson R Jemth AS, Gustafsson NM Färnegårdh Loseva Wiita Bonagas Dahllund Llona-Minguez Häggblad Henriksson Andersson Homan Helleday Stenmark K O E N L S M M Y E T P

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Journal Article

Cancer res, 77 (4), pp. 937-948, 2017.

Abstract | Links | BibTeX | Tags: article

Thålin C Daleskog M, Göransson SP Schatzberg Lasselin Laska AC Kallner Helleday Wallén Demers D J A T H M

Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma. Journal Article

Immunol Res. , 2017.

Abstract | Links | BibTeX | Tags: article

Ogris C Guala D, Helleday Sonnhammer EL. T

A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation. Journal Article

Nucleic Acids Res., 2017.

Links | BibTeX | Tags: article

2016

Tanikawa M1 Sanjiv K1, Helleday Herr Mortusewicz T1 P1 O1

The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing Journal Article

Oncogenesis, 5 (12), pp. e280, 2016.

Links | BibTeX | Tags: article

Eshtad S Mavajian Z, Rudd SG Visnes Boström Altun Helleday T J M T

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Journal Article

Oncogenesis, 2016.

Abstract | Links | BibTeX | Tags: article

Valerie NC Hagenkort A, Page BD Masuyer Rehling Carter Bevc Herr Homan Sheppard NG Stenmark Jemth AS Helleday G D M L P E P T

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. Journal Article

pp. 5501-11, 2016.

Abstract | Links | BibTeX | Tags: article

Ogris C Helleday T, Sonnhammer EL.

PathwAX: a web server for network crosstalk based pathway annotation. Journal Article

Nucleic Acids Res., 2016.

Abstract | Links | BibTeX | Tags: article

Jackson SP, Helleday T

DNA REPAIR. Drugging DNA repair. Journal Article

Science, 352 (6290), pp. 1178-9, 2016.

Links | BibTeX | Tags: article

Rudd SG Valerie NC, Helleday T

Pathways controlling dNTP pools to maintain genome stability. Journal Article

DNA repair, (44), pp. 193-204, 2016.

Abstract | Links | BibTeX | Tags: article

Llona-Minguez S Höglund A, Jacques SA Johansson Calderón-Montaño JM Claesson Loseva Valerie NC Lundbäck Piedrafita Maga Crespan Meijer Burgos Morón Baranczewski Hagbjörk AL Svensson Wiita Almlöf Visnes Jeppsson Sigmundsson Jensen AJ Artursson Jemth AS Stenmark Warpman Berglund Scobie L M O T J G E L E P R E I T F K P P U M; T, Helleday

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Journal Article

J Med Chem, 59 (3), pp. 1140-8, 2016.

Abstract | Links | BibTeX | Tags: article

2015

Puigvert JC, Sanjiv K; T., Helleday

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies. Journal Article

FEBS J, 282 (2), pp. 232-45, 2015.

Abstract | Links | BibTeX | Tags: article

There are 2 major kinds of motorcycle chanel replica saddlebags. Throw over saddlebags and hard mount saddlebags. The concept of hard mount saddlebags originated from throw over saddlebags which were used in early 1950 for your first time. As the motorcycle business experienced a big boom in 1960 especially after the chanel replica sale the motorcycle luggage also evolved. As major motorcycle companies launched bigger and better motorcycle folks chanel replica sale began traveling farther on there motorcycles. Many riders formed groups and chanel replica rode cross country and from city to city. Chanel replica handbags outlet is your trusting choosing. This permanent installation resulted in the saddlebags is more reliable and sturdy.