DNA damage and repair in cancer
Many DNA damaging anti-cancer drugs cause replication-associated DNA damage that kill cancer cells.
The MTH1 Story
Fueled by the responses obtained in cancer patients with PARP inhibitors, we and many others were very enthusiastic about identifying novel synthetic lethal approaches for treatment of cancer. However, soon after the initial responses in patients we were also reached by the news that resistance to PARP inhibitors emerged in a similar manner as seen with other types of targeted therapies, aiming to target the cancer genotype.
DNA replication, repair and transcription
The mammalian genome has to be constantly copied (replication), read (transcription) and repaired (DNA repair) which poses a great challenge to eukaryotic cells.