Selected publications

Selected original and review articles

Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderón-Montaño JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter JI, Helleday T, Schaller T. (2017)


Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Nat Med. 2017 Jan 9. doi: 10.1038/nm.4265. [Epub ahead of print]

Jackson SP#, Helleday T#. (2016)

Drugging DNA repair.

Science. 352(6290):1178-9. (# co-corresponding authors)

Helleday T. (2015)


Poisoning Cancer Cells with Oxidized Nucleosides.


N Engl J Med. 373(16):1570-1.

Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J, Warpman Berglund U, Helleday T#, Stenmark P#. (2015)


Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.


Nature Communications 6:7871 (# co-corresponding author)

Xie S, Mortusewicz O, Ma HT, Herr P, Poon RR, Helleday T#, Qian C#. (2015)


Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.


Mol Cell. 60(1):163-76. (# co-corresponding author)

Tarish FL, Schultz N, Tanoglidi A, Hamberg H, Letocha H, Karaszi K, Hamdy FC, Granfors T, Helleday T. (2015)


Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair.


Sci Transl Med. 7(312):312re11

Huber K, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth A-S, Gokturk C, Sanjiv K, Pham T, Warpman Berglund U, Colinge J, Bennett KL, Loizou J, Helleday T, Knapp S, Superti-Furga G  (2014)


Stereospecific targeting of the genome integrity protein MTH1 in Ras-dependent cancer with (S)-crizotinib.


Nature. 508(7495):222-7.

Gad H, Koolmeister T, Jemth A-S, Eshtad S, Jacques SA, Ström CE, Svensson LM, Einarsdottir B, Schultz N, Lundbäck T, Saleh A, Gokturk C, Baranczewski P, Svensson R, Strömberg K, Bräutigam L, Jacques-Cordonnier M-C, Desroses M, Gustavsson A-L, Berntsson RPA, Gustafsson R, Olofsson R, Vikingsson S, Johansson F, Loseva O, Sanjiv K, Johansson L, Höglund A, Hagenkort A, Pham T,  Altun M, Gaugaz FZ, Evers B, Henriksson M, Vallin K, Wallner O,  Hammarström LGJ, Wiita E, Almlöf I, Axelsson H, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jenmalm Jensen A, Artursson P, Nilsson JA, Stenmark P, Scobie M, Warpman Berglund U, Helleday T (2014)


MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.


Nature. 508(7495):215-21.

Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi O, Halazonetis TD (2014)


Break-induced replication repair of damaged forks induces genomic duplications in human cells.


Science. 343:88-91.

Helleday T#, Esthad S, Nik-Zainal S# (2014)


Mechanisms underlying mutational signatures in human cancers.


Nature Reviews Genetics 15 (9), 585-598. (#co-corresponding authors)

Mortusewicz O, Herr P, Helleday T. (2013)


Early replication fragile sites: where replication-transcription collisions cause genetic instability.


EMBO J. 32(4):493-5.

Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C. (2013)


Replication stress links structural and numerical cancer chromosomal instability.


Nature. 494(7438):492-6.

Petermann E, Woodcock M, Helleday T (2010)


Chk1 promotes replication fork progression by controlling replication initiation.


Proc Natl Acad Sci USA, 107:16090-5.

Petermann E, Orta L, Issaeva N, Schultz N and Helleday T (2010)


Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51- mediated pathways for restart and repair.


Molecular Cell, 37, 492-502.

Bryant HE, Petermann E, Schultz N, Jemth A-S, Issaeva N, Johansson F, Fernandez S, McGlynn P, Helleday T (2009)


PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

EMBO J, 28, 2601-15.

Bartkova, J.,  Rezaei, N., Liontos, M., Karakaidos, P., Vassiliou, L.V.F., Issaeva, N., Kletsas, D., Kolettas, E., Niforou, K., Zoumpourlis, V.C., Takaoka, M., Nakagawa, H., Tort, F., Fugger, K., Johansson, F., Sehested, F., Andersen, C.L., Dyrskjot, L., Orntoft, T., Lukas, J., Kittas, C., Helleday, T., Halazonetis, T.D., Bartek, J., Gorgoulis, V.G. (2006)

Oncogene-induced senescence is an integral part of the tumorigenesis barrier imposed by DNA damage checkpoints.


Nature, 444(7119), 633-7.

Bryant, H.E., Schultz, N, Thomas, H.D., Parker, K.M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N.J., Helleday, T. (2005)


Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose)polymerase.


Nature, 434, 913-7.

Sørensen, C.S., Hansen, L.T., Dziegielewski, J., Syljuåsen, R.G., Lundin, C., Bartek, J.#, Helleday, T.# (2005)


The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

Nature Cell Biology, 7(2), 195-201. (# co-correspondent authors)


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