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Welcome Dr Åsa Rosenquist
A few years ago, when west Africa was plagued by an devastating Ebola outbreak, we tried out our protein inhibitors on the Ebola virus. We were delighted when we realized we’d found a group of substances that not only effectively killed the the Ebola virus, but also a...
Congratulations Saeed Eshtad, PhD!
The Helleday lab wishes to congratulate Saeed Eshtad on a successful thesis defence on Monday February 13th! Saeeds’s thesis is called “Targeting DNA repair pathways for cancer therapy” and the aim of the thesis was to identify and understand if factors important in...
Our metabolic target MTHFD2 crystal structure now resolved with inhibitor
The MTHFD2 protein is uniquely expressed in cancer and not in normal tissue. Yet, it is required for survival in cancer, but not for normal cells. This makes it a highly interesting target, with the potential of finding compounds that selectively kill cancer cells,...
The Helleday Team presents potent MTH1 inhibitor ‘Karonudib’ and experimentally addresses the non-active MTH1 inhibitors.
The Helleday Team proudly presents our new potent MTH1 inhibitor Karonudib, which is 20 times more effective than the previously described TH588 inhibitor, recently published in Annals of Oncology. Karonudib stands for: Karolinska nudt1 (MTH1 gene name) inhibitor. In...
The drugs of the future will target DNA repair
Keeping up the intact DNA is vital for all organisms, and life as we know of it would not exist. Now, we know it is not black or white, but that DNA damage can also lead to imperfection leading to various diseases. Ageing is an example of a process that will damage...
Helleday Lab congratulates Oskar Fernandez-Capetillo and Dana Branzei becoming new EMBO members
Today Oskar Fernandez-Capetillo and Dana Branzei were elected as members into the prestigious EMBO organisation, which is an organization of more than 1700 leading researchers that promotes excellence in the life sciences. The major goals of the organization are to...