Thomas Helleday

Professor

Thomas Helleday is Swedish and obtained his first degree in molecular biology at the Stockholm University (1995). Alongside these studies, he took a degree in Business Administration and Economics at the same university (1996). In 1999, he was awarded a PhD from Stockholm University for his studies on homologous recombination in mammalian cells.

After a short post-doctoral research period with Mark Meuth at the Institute for Cancer Research, Sheffield, UK, he obtained a lectureship at the same institute and set up his own group, with an interest in homologous recombination at replication forks in mammalian cells. At the same time, he maintained grants and a position at the Stockholm University, allowing his group to continue research at the Department of Genetics, Microbiology and Toxicology. Thomas Helleday became professor at both University of Sheffield and Stockholm University in 2006, prior to be recruited as MRC Professor of Cancer Therapeutics at the Gray Institute for Radiation Oncology and Biology at the University of Oxford,. Currently, Thomas Helleday is the Torsten and Ragnar Söderberg Professor of Translational Medicine and Chemical Biology at Science for Life Laboratory at the Karolinska Institutet Science Park in Stockholm. Thomas Helleday heads Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet. He has won numerous prestigious prizes including the ERC Advanced Grant Award twice 2010 and 2016, Cancer researcher of the year 2016 by the Swedish Cancer SocietyErik K Fernström Prize in Medicine 2014, Göran Gustafsson Prize in Medicine 2013, Skandia’s Lennart Levi Prize at Karolinska Institutet 2012.

Carcinogenesis Young Investigator Award 2010, the Swiss Bridge Award 2008 by Swiss Cancer League and the International Union Against Cancer (UICC), the Svedberg Award 2008 by SFBM and Swedish National Committee for Molecular Biosciences, the European Association for Cancer Research Young Cancer Researchers Award 2007, the Royal Swedish Academy of Sciences’ Hilda and Alfred Eriksson’s prize 2007 for an outstanding research contribution in relief of diseases in man or animal, British Association for Cancer Research (BACR) – AstraZeneca Young Scientist Frank Rose Award 2006, the Eppendorf-Nature Young European Investigator Award 2005 for outstanding contribution within the field of biomedical science and the European Environmental Mutagen Society (EEMS) Young Scientist Award 2005. The current focus in the Helleday laboratories is understanding and exploiting altered nucleotide metabolism and DNA repair at replication forks for novel anti-cancer therapies.


Thomas Helleday

Professor

Resume

Thomas Helleday is Swedish and obtained his first degree in molecular biology at the Stockholm University (1995). Alongside these studies, he took a degree in Business Administration and Economics at the same university (1996). In 1999, he was awarded a PhD from Stockholm University for his studies on homologous recombination in mammalian cells.

After a short post-doctoral research period with Mark Meuth at the Institute for Cancer Research, Sheffield, UK, he obtained a lectureship at the same institute and set up his own group, with an interest in homologous recombination at replication forks in mammalian cells. At the same time, he maintained grants and a position at the Stockholm University, allowing his group to continue research at the Department of Genetics, Microbiology and Toxicology. Thomas Helleday held two professorships; one as MRC Professor of Cancer Therapeutics at the Gray Institute for Radiation Oncology and Biology at the University of Oxford,and the other as Professor of Molecular Genetics at the Department of Genetics, Microbiology and Toxicology at Stockholm University.

Many DNA damaging anti-cancer drugs cause replication-associated DNA damage that kill cancer cells. This is an effective way of treating cancer, but the problem is that also normal cells are damaged. Our strategy is to exploit the high level of DNA damage in cancer cells and prevent the repair of these lesions. Using DNA repair inhibitors, we can selectively introduce toxic DNA damage to cancer cells.

Currently, Thomas Helleday is the Torsten and Ragnar Söderberg Professor of Translational Medicine and Chemical Biology at Science for Life Laboratory at the Karolinska Institutet Science Park in Stockholm. Thomas Helleday heads Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet. He has won numerous prestigious prizes including the Carcinogenesis Young Investigator Award 2010, the Swiss Bridge Award 2008 by Swiss Cancer League and the International Union Against Cancer (UICC), the Svedberg Award 2008 by SFBM and Swedish National Committee for Molecular Biosciences, the European Association for Cancer Research Young Cancer Researchers Award 2007, the Royal Swedish Academy of Sciences’ Hilda and Alfred Eriksson’s prize 2007 for an outstanding research contribution in relief of diseases in man or animal, British Association for Cancer Research (BACR) – AstraZeneca Young Scientist Frank Rose Award 2006, the Eppendorf-Nature Young European Investigator Award 2005 for outstanding contribution within the field of biomedical science and the European Environmental Mutagen Society (EEMS) Young Scientist Award 2005. The current focus in the Helleday laboratories is understanding and exploiting DNA repair and DNA-damage signalling pathways at replication forks for novel anti-cancer therapies

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