Recently, organocatalysis has become available as a technology to modulate enzyme function in DNA repair. In a ternary complex of enzyme and intermediate repair product, small molecules optimized for this three-dimensional architecture initiate an artificial destruction of the DNA substrate, which in turn may lead to uncommon or natural repair products – opening possibilities for both acceleration or obstruction of DNA repair.
What is the task?
For the broadening of the technology base of organocatalytic enzyme activation in DNA repair, the Medicinal Chemistry team is looking for one Postdoctoral Researcher. The position comes with the following tasks:
What are the requirements?
– a PhD or equivalent in heterocyclic, organocatalytic, medicinal or organic chemistry
– experience in supervision of first cycle students
– project lead experience is merited
– significant experience in teamwork and adaptability in interdisciplinary projects as demonstrated through high-profile publication
What are we offering?
We are at the forefront of developing our breakthrough technology of establishing new enzymatic functions in DNA repair. You will work in a world-class lab at Science for Life Laboratory Solna, affiliated with the Department of Oncology and Pathology at Karolinska Institute. The team consists of chemists, biochemists, biologists, pharmacologists and data scientist with backgrounds from industry and academia. Our strong collaborative network within EUbOPEN ensures access to complementary expert knowledge and state of the art techniques, including regular in person meetings. We foster a mentorship-first attitude that prioritizes personal development, educating the next generation of independent researchers. The position is supported by a scholarship of the Thomas Helleday Foundation for medical research with competitive market salary and runs for one year with a good possibility to be further prolonged. Income in Sweden comes with governmental funded health care, a cap for health-care related spendings, as well as affordable childcare.
What is the next step?
Soon-to-be graduated PhD students welcome. Career Age after PhD: maximum 2 years.
Deadline 2nd of April 2023.