Prisregn över Helledaylaboratoriets Sean Rudd

Vår postdoc Sean Rudd har hittills haft en riktigt bra vecka. I onsdags belönades han med priset ”SciLifeLab Highlight of the year 2016″ på SciLifeLab summit här i Solna, och igår kom beskedet att Sean har fått 200 000kr från Alex och Eva Wallströms stiftelse för hans arbete med SAMHD1. Stort grattis Sean!   (Foto […]

A great week so far for Helleday Laboratory postdoc Sean Rudd

Our postdoc fellow Sean Rudd is having a good week so far. On Wednesday he was awarded the ”SciLifeLab Highlight of the year 2016”- prize at the SciLifeLab summit, and yesterday he received 200 000 SEK from the Alex and Eva Wallström Foundation for a proposal on SAMHD1! Congratulations and well done Sean!   (photo by […]

Welcome Dr Åsa Rosenquist

A few years ago, when west Africa was plagued by an devastating Ebola outbreak, we tried out our protein inhibitors on the Ebola virus. We were delighted when we realized we’d found a group of substances that not only effectively killed the the Ebola virus, but also a range of other viruses as well. Our data […]

Välkommen Åsa!

När det stora ebolautbrottet skedde för ett par år sedan testade vi våra proteinhämmare för att se om de kunde användas till att döda av ebolavirus. Till vår förvåning hittade vi en substansfamilj som inte bara effektivt dödade av ebolaviruset utan också en rad andra virus i cellerna. Våra data visar att behandlingen också fungerar […]

Congratulations Saeed Eshtad, PhD!

The Helleday lab wishes to congratulate Saeed Eshtad on a successful thesis defence on Monday February 13th! Saeeds’s thesis is called “Targeting DNA repair pathways for cancer therapy” and the aim of the thesis was to identify and understand if factors important in DNA repair of lesions caused by oxidative stress can be targeted to […]

Grattis Saeed Eshtad!

Ett stort grattis till nyblivne Fil.dr Saeed Eshtad som framgångsrikt disputerade med sin avhandling “ Targeting DNA repair pathways for cancer therapy” den 13 februari. Handledare till Saeed var Thomas Helleday och opponent var professor Arne Klungland från Oslo universitetssjukhus. Vill du läsa avhandlingen så finns den att hämta här. Fil.dr Saeed Eshtad och professor […]

Our metabolic target MTHFD2 crystal structure now resolved with inhibitor

The MTHFD2 protein is uniquely expressed in cancer and not in normal tissue. Yet, it is required for survival in cancer, but not for normal cells. This makes it a highly interesting target, with the potential of finding compounds that selectively kill cancer cells, but not normal cells. Key to success is to determine the […]

The Helleday Team presents potent MTH1 inhibitor ‘Karonudib’ and experimentally addresses the non-active MTH1 inhibitors.

The Helleday Team proudly presents our new potent MTH1 inhibitor Karonudib, which is 20 times more effective than the previously described TH588 inhibitor, recently published in Annals of Oncology. Karonudib stands for: Karolinska nudt1 (MTH1 gene name) inhibitor. In a new report published in Annals of Oncology we present that Karonudib has excellent anti-tumour activity […]

Thomas Helledays receives ERC Advanced Grant

Thomas Helleday is one of nine scientists receiving a grant of 2.5 million euros over five years from the European Research Council. Research proposed for funding to the ERC should aim high, both with regards to the ambition of the envisaged scientific achievements as well as to the creativity and originality of proposed approaches. The […]

Helleday Laboratory anställer projektledare inför kommande kliniska prövningar

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